Description
Parkinson et parkinsonismes
- The abnormal audiovisual conflict in Parkinson's disease patients is manifested in perception rather than response
Sci Rep. 2025 Apr 15;15(1):12961. doi: 10.1038/s41598-025-86313-3.ABSTRACTAudiovisual conflict control is a crucial cognitive function in humans. However, it remains unclear whether and how abnormal […]
- Diagnosing Parkinson's disease via behavioral biometrics of keystroke dynamics
Sci Adv. 2025 Apr 4;11(14):eadt6631. doi: 10.1126/sciadv.adt6631. Epub 2025 Apr 4.ABSTRACTParkinson's disease (PD) is one of the rapidly growing neurodegenerative diseases, affecting more than 10 […]
- Explainable artificial intelligence to diagnose early Parkinson's disease via voice analysis
Sci Rep. 2025 Apr 5;15(1):11687. doi: 10.1038/s41598-025-96575-6.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder affecting motor control, leading to symptoms such as tremors and […]
- Precision Medicine in Parkinson's Disease
Neurol Clin. 2025 May;43(2):365-381. doi: 10.1016/j.ncl.2024.12.011. Epub 2025 Feb 5.ABSTRACTThe continually accumulating knowledge of Parkinson's disease (PD) genetics presents potential disease […]
- Advice to people with Parkinson's in my clinic: Get a cardiopulmonary exercise test
J Parkinsons Dis. 2025 Apr 13:1877718X251330814. doi: 10.1177/1877718X251330814. Online ahead of print.ABSTRACTAerobic (cardiopulmonary) exercise training improves fitness and limits the progression […]
- Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Sci Adv. 2025 Apr 11;11(15):eadp8504. doi: 10.1126/sciadv.adp8504. Epub 2025 Apr 11.ABSTRACTRNA editing is a posttranscriptional mechanism that targets changes in RNA transcripts to modulate innate […]
- Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson's disease-like neurodegeneration
Fluids Barriers CNS. 2025 Apr 14;22(1):38. doi: 10.1186/s12987-025-00646-9.ABSTRACTParkinson's disease (PD) is a neurodegenerative illness characterized by motor and non-motor features. Hallmarks of […]
- Prioritizing Parkinson's disease risk genes in genome-wide association loci
NPJ Parkinsons Dis. 2025 Apr 16;11(1):77. doi: 10.1038/s41531-025-00933-0.ABSTRACTMany drug targets in ongoing Parkinson's disease (PD) clinical trials have strong genetic links. While genome-wide […]
- Volumetric Changes in Cerebellar Transverse Zones: Age and Sex Effects in Health and Neurological Disorders
Hum Brain Mapp. 2025 Apr 15;46(6):e70214. doi: 10.1002/hbm.70214.ABSTRACTCerebellar volumetric changes are intricately linked to aging, with distinct patterns across its transverse zones, the […]
- Gradients of Nigrostriatal Iron Deposition in Healthy Aging and Synucleinopathies
CNS Neurosci Ther. 2025 Mar;31(3):e70359. doi: 10.1111/cns.70359.ABSTRACTAIMS: To investigate the gradients of nigrostriatal iron deposition in aging, Parkinson's disease (PD), and multiple system […]
Traitements pharmacologiques
Médicaments
- Exploring bioactive natural products for treating neurodegenerative diseases: a computational network medicine approach targeting the estrogen signaling pathway in amyotrophic lateral sclerosis and Parkinson's disease
Metab Brain Dis. 2025 Apr 4;40(4):169. doi: 10.1007/s11011-025-01585-y.ABSTRACTAmyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) share overlapping molecular mechanisms, including […]
- The effects of dopaminergic medication and task load on trembling and akinetic freezing of gait in Parkinson's disease
J Neurol. 2025 Mar 28;272(4):296. doi: 10.1007/s00415-025-13023-1.ABSTRACTBACKGROUND: In people with Parkinson's disease (PD), freezing of gait (FOG) can manifest as an absence of leg movement […]
- Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia
J Neural Transm (Vienna). 2025 Mar 26. doi: 10.1007/s00702-025-02914-2. Online ahead of print.ABSTRACTLevodopa remains central to Parkinson's disease (PD) treatment, but long-term use can cause motor […]
- Rationally designed peptides inhibit the formation of α-synuclein fibrils and oligomers
Eur J Med Chem. 2025 May 5;289:117452. doi: 10.1016/j.ejmech.2025.117452. Epub 2025 Feb 26.ABSTRACTParkinson's Disease (PD) is characterized by the pathological aggregation of α-synuclein (αSyn) […]
- Abnormal arm swing movements in Parkinson's disease: onset, progression and response to L-Dopa
J Neuroeng Rehabil. 2025 Mar 4;22(1):47. doi: 10.1186/s12984-025-01589-w.ABSTRACTBACKGROUND: Reduced arm swing movements during gait are an early motor manifestation of Parkinson's disease (PD). The […]
Études cliniques phase 3 et phase 4
- GLP-1 agonists to slow down Parkinson's progression? The quest continues
Med. 2025 Apr 11;6(4):100645. doi: 10.1016/j.medj.2025.100645.ABSTRACTA much-anticipated phase 3 clinical trial (EXENATIDE-PD3) tested whether exenatide, a GLP-1 receptor agonist used to treat type 2 […]
- AZP2006 (Ezeprogind®): a Promising New Drug Candidate in the Battle Against Neurodegenerative Diseases
ChemMedChem. 2025 Mar 27:e202400891. doi: 10.1002/cmdc.202400891. Online ahead of print.ABSTRACTProgressive Supranuclear Palsy (PSP) is a rare neurodegenerative disorder characterized by abnormal tau […]
- Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson's disease
Mol Brain. 2025 Apr 4;18(1):29. doi: 10.1186/s13041-025-01200-2.ABSTRACTBACKGROUND: Parkinson's disease (PD), a globally prevalent neurodegenerative disorder, has been implicated with oxidative […]
- Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease in the UK: a phase 3, multicentre, double-blind, parallel-group, randomised, placebo-controlled trial
Lancet. 2025 Feb 4:S0140-6736(24)02808-3. doi: 10.1016/S0140-6736(24)02808-3. Online ahead of print.ABSTRACTBACKGROUND: GLP-1 receptor agonists have neurotrophic properties in in-vitro and in-vivo […]
- Drug Repositioning and Repurposing for Disease-Modifying Effects in Parkinson's Disease
J Mov Disord. 2025 Feb 7. doi: 10.14802/jmd.25008. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most prevalent neurodegenerative disorder and is characterized by progressive […]
Traitements non pharmacologiques
Chirurgie
- Evaluating the efficacy and acceptability of non-invasive brain stimulation for generalized anxiety disorder: a systematic review and network meta-analysis
Psychiatry Res Neuroimaging. 2025 Apr 4;349:111989. doi: 10.1016/j.pscychresns.2025.111989. Online ahead of print.ABSTRACTNon-invasive brain stimulation (NIBS) has the potential to treat generalized […]
- Non-invasive brain stimulation for borderline personality disorder: a systematic review and network meta-analysis
Ann Gen Psychiatry. 2025 Apr 16;24(1):24. doi: 10.1186/s12991-025-00561-1.ABSTRACTINTRODUCTION: Borderline Personality Disorder (BPD) is a complex neuropsychiatric condition characterized by four […]
- Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders
Fundam Res. 2024 Jul 6;5(1):48-54. doi: 10.1016/j.fmre.2024.06.009. eCollection 2025 Jan.ABSTRACTGrowing evidence supports the effectiveness of deep brain stimulation (DBS) in treating various […]
- Olfactory changes in patients with Parkinson's disease undergoing deep brain stimulation in the subthalamic nucleus: a systematic review and meta-analysis
Neurosurg Rev. 2025 Mar 27;48(1):333. doi: 10.1007/s10143-025-03479-0.ABSTRACTDeep brain stimulation in the subthalamic nucleus (STN-DBS) is a therapeutic intervention for patients with Parkinson's […]
- The Efficacy and Acceptability of Non-Invasive Brain Stimulation Interventions for Obsessive-Compulsive Disorder Management: A Network Meta-Analysis Based on 24 Stimulation Methods
Acta Psychiatr Scand. 2025 Mar 31. doi: 10.1111/acps.13809. Online ahead of print.ABSTRACTINTRODUCTION: Despite the high lifetime prevalence and elevated disability rates, treatments for […]
Approches multidisciplinaires
- Rehabilitation of Women with Neurodegenerative Diseases
Phys Med Rehabil Clin N Am. 2025 May;36(2):389-398. doi: 10.1016/j.pmr.2024.11.006. Epub 2024 Dec 10.ABSTRACTParkinson's disease, multiple sclerosis, and Alzheimer's disease are 3 prevalent […]
- Cognition and obstructive sleep apnea in Parkinson's disease: randomized controlled trial of positive airway pressure (COPE-PAP trial)
Sleep. 2025 Feb 13:zsaf038. doi: 10.1093/sleep/zsaf038. Online ahead of print.ABSTRACTSTUDY OBJECTIVES: This randomized controlled trial assessed the effects of positive airway pressure (PAP) […]
- Effect of power training on physical functional performance of patients with Parkinson's disease: A systematic review and meta-analysis of randomized controlled trials
PLoS One. 2025 Feb 4;20(2):e0314058. doi: 10.1371/journal.pone.0314058. eCollection 2025.ABSTRACTINTRODUCTION: Parkinson's disease (PD) is becoming more prevalent, highlighting the urgency of […]
- Quality of Life and non-motor symptoms Improvement in Parkinson's Disease through Nutritional Intervention: a Case Study
J Prev Med Hyg. 2025 Jan 31;65(4):E555-E562. doi: 10.15167/2421-4248/jpmh2024.65.4.3322. eCollection 2024 Dec.ABSTRACTNon-motor symptomatology in Parkinson's disease (PD) is related to patients' […]
- Optimal dose and type of exercise improve walking velocity in adults with Parkinson's disease: a systematic review and Bayesian network meta-analysis
Sci Rep. 2025 Jan 17;15(1):2239. doi: 10.1038/s41598-025-85456-7.ABSTRACTTo examine the dose-response relationship between specific types of exercise for improving walking velocity in Parkinson's […]
Thérapies alternatives
- Physiotherapy and Exercise in Parkinson's Disease
Neurol Clin. 2025 May;43(2):427-443. doi: 10.1016/j.ncl.2024.12.014. Epub 2025 Jan 24.ABSTRACTPhysiotherapy is an important treatment strategy in Parkinson's disease. Guidelines recommend early and […]
- Is physical therapy recommended for people with parkinson's disease treated with subthalamic deep brain stimulation? a delphi consensus study
J Neuroeng Rehabil. 2025 Apr 10;22(1):80. doi: 10.1186/s12984-025-01616-w.ABSTRACTBACKGROUND: Although deep brain stimulation of the subthalamic nucleus (STN-DBS) induces motor benefits in people […]
- Massage-Mimicking Nanosheets Mechanically Reorganize Inter-organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease
Adv Sci (Weinh). 2025 Apr 13:e2413376. doi: 10.1002/advs.202413376. Online ahead of print.ABSTRACTParkinson's disease (PD) is exacerbated by dysfunction of inter-organelle contact, which depends on […]
- Unconventional exercises for motor function in Parkinson's disease: an umbrella review of meta-analyses
Age Ageing. 2025 Mar 3;54(3):afaf062. doi: 10.1093/ageing/afaf062.ABSTRACTBACKGROUND: Unconventional exercises were initially used in the clinical treatment of Parkinson's disease (PD). However, […]
- Pain and the Non-Pharmacological Management of Pain in People with Parkinson's Disease
J Parkinsons Dis. 2024;14(s1):S65-S80. doi: 10.3233/JPD-230227.ABSTRACTPain is a distressing and universal experience, yet everyone's pain experience is influenced by a complex array of biological, […]
Qualité de vie des patients
Expérience patient
- The relationship between physical function and psychological symptoms in Parkinson's: Perceptions of People with Parkinson's and Carers
PLoS One. 2025 Apr 15;20(4):e0310578. doi: 10.1371/journal.pone.0310578. eCollection 2025.ABSTRACTBACKGROUND: People with Parkinson's (PwP) can experience both physical and psychological symptoms, […]
- Exploring stigma in people living with Parkinson's disease and their caregivers: A review of qualitative studies
J Parkinsons Dis. 2025 Apr 13:1877718X251330995. doi: 10.1177/1877718X251330995. Online ahead of print.ABSTRACTBackground: Stigma deeply affects individuals living with Parkinson's disease (PD), […]
- Impact of hypersexuality on spousal carers of patients with Parkinson's disease and frontotemporal dementia: a qualitative study
BMJ Open. 2025 Apr 10;15(4):e090870. doi: 10.1136/bmjopen-2024-090870.ABSTRACTOBJECTIVES: Hypersexuality involves an inability to control intense, recurring sexual impulses, resulting in repetitive […]
- Physiotherapy and Exercise in Parkinson's Disease
Neurol Clin. 2025 May;43(2):427-443. doi: 10.1016/j.ncl.2024.12.014. Epub 2025 Jan 24.ABSTRACTPhysiotherapy is an important treatment strategy in Parkinson's disease. Guidelines recommend early and […]
- Fears and uncertainties of people with Parkinson's disease
J Parkinsons Dis. 2025 Apr 3:1877718X251328565. doi: 10.1177/1877718X251328565. Online ahead of print.ABSTRACTBackgroundThe patient experience of Parkinson's disease (PD) is heterogeneous, with […]
Technologies de soutien
- The effects of task-specific home-based touchscreen training in people with Parkinson's disease: a pilot randomized controlled trial
J Neurol. 2025 Apr 9;272(5):328. doi: 10.1007/s00415-025-13065-5.ABSTRACTBACKGROUND: Manual dexterity deficits impair the ability to effectively use touchscreen devices in people with Parkinson's […]
- Modernizing the Staging of Parkinson Disease Using Digital Health Technology
J Med Internet Res. 2025 Apr 4;27:e63105. doi: 10.2196/63105.ABSTRACTDue to the complicated nature of Parkinson disease (PD), a number of subjective considerations (eg, staging schemes, clinical […]
- Digital health technology for Parkinson's disease with comprehensive monitoring and artificial intelligence-enabled haptic biofeedback for bulbar dysfunction
J Parkinsons Dis. 2025 Apr 4:1877718X251329354. doi: 10.1177/1877718X251329354. Online ahead of print.ABSTRACTBackgroundParkinson's disease (PD) is the second most prevalent neurodegenerative […]
- Effect of the Yon PD App on the Management of Self-Care in People With Parkinson Disease: Randomized Controlled Trial
J Med Internet Res. 2025 Apr 2;27:e62822. doi: 10.2196/62822.ABSTRACTBACKGROUND: As the percentage of the older population increases, it is accompanied by an increase in the prevalence of Parkinson […]
- Patient Acceptability and Technical Reliability of Wearable Devices Used for Monitoring People With Parkinson Disease: Survey Study
JMIR Form Res. 2025 Mar 25;9:e63704. doi: 10.2196/63704.ABSTRACTBACKGROUND: Parkinson disease is a progressive neurodegenerative disorder with complex motor and nonmotor symptoms. To assess these, […]
Associations et ordres professionnels
Québec
- Infolettre Parkinson - Avril 2025 💙on 17 avril 2025
🎗️ Avril – Mois de sensibilisation à la maladie de Parkinson Cliquez ici pour visualiser l'infolettre dans votre navigateur […]
- 🔎 Souhaitez-vous contribuer à la recherche sur la maladie de Parkinson?on 24 mars 2025
🔎 Souhaitez-vous contribuer à la recherche sur la maladie de Parkinson? Développement de la version francophone de l’échelle de kinésiophobie de Tampa pour la maladie de Parkinson […]
- Journée scientifique sur la maladie de Parkinson – 8 avril 2025 🔬on 24 mars 2025
Journée scientifique sur la maladie de Parkinson – 8 avril 2025 🔬 Nous sommes fiers de commanditer la journée scientifique organisée par le groupe de chercheurs de l’Université de […]
- Formulaire Hyperhidroseon 24 mars 2025
📝 Votre opinion est précieuse ! Vous ou un proche êtes concerné par la maladie de Parkinson ? Prenez quelques minutes pour répondre à 6 courtes questions sur l’hyperhidrose. 💡 […]
- La dynamique familialeon 24 mars 2025
🎙 Nouvel épisode de En Quête de Dopamine : La dynamique familiale. Lorsque la maladie de Parkinson entre dans une famille, elle redéfinit les rôles, les responsabilités et les relations. […]
Canada
- Choisir la vie : Notre voyage avec la maladie de Parkinsonon 17 avril 2025
Le point de vue de Peter : La vie avec la maladie de Parkinson ne m’a pas ralentie, pas dans les domaines qui comptent. Je me lève encore tous les matins avec un but précis, je jardine […]
- Nouvelles recherches sur le lien entre le gène CTSB et la maladie de Parkinsonon 17 avril 2025
Exposé sommaire Les chercheurs ont analysé les différences entre les variantes du gène CTSB, qui est associé à la fonction cellulaire et joue un rôle potentiel dans une variété de […]
- Résumé de l’atelier sur l’engagement des patients à Saskatoonon 17 avril 2025
L’équipe de recherche de Parkinson Canada a organisé le 22 octobre à Saskatoon le troisième événement de notre série d’ateliers 2024 sur l’engagement des patients dans la recherche sur […]
- Gut Health and Its Effect on Brain Functionon 17 avril 2025
By Rakhi Amirah Khurana […]
- Taking Control of Your Future: Why Advance Care Planning Day Matters for Your Health and Peace of Mind on 17 avril 2025
By David Kua April 16th is Advance Care Planning Day in Canada! Every day, we make countless decisions—some small, some big and others life-altering. Yet, among all these choices, one of the […]
États-Unis
- AAN 2025: Crexont improves sleep quality in Parkinson’s patientson 17 avril 2025
- New targeted approach protects neurons from degeneration: Studyon 17 avril 2025
- Lessons I’ve learned while being a Parkinson’s caregiveron 17 avril 2025
- Songbirds spark insights into role of dopamine in learning: Studyon 17 avril 2025
- Magic Mushrooms for Parkinson’s?on 17 avril 2025
- Could Oxygen Deprivation Treat Parkinson’s Disease?on 17 avril 2025
- Wearable sensors may help monitor, ease Parkinson’s swallowing issueson 17 avril 2025
- Immune suppression proposed as way to slow Parkinson’s progressionon 17 avril 2025
- Excess exercise may worsen Parkinson’s symptoms, report sayson 17 avril 2025
- Stem cells to treat Parkinson's? 2 small studies hint at successon 17 avril 2025
International
- Parkinson’s Europe advocates for improved healthcare at European Parliament eventon 17 avril 2025
Parkinson’s Europe shared key statistics and advocated for improved healthcare for people with Parkinson’s at a recent event in Brussels. The working group event, “Europe’s leading role in […]
- Journée mondiale Parkinson 2025on 17 avril 2025
Journée mondiale Parkinson 2025 France Parkinson alerte sur l’augmentation inquiétante du nombre de personnes malades. Il est urgent d’agir ! […]
- CP Glyphosate : 4 associations devant la justice européenne pour contester sa réautorisationon 17 avril 2025
CP Glyphosate : 4 associations devant la justice européenne pour contester sa réautorisation Accueil > Actualités > CP […]
- Women and Parkinson’s: gender differences should be a priority for researchers, new report sayson 20 janvier 2025
A new report highlights gender differences in Parkinson's, and has identified a number of ways to improve care for women with Parkinson's. The post Women and Parkinson’s: gender differences should […]
- L’activité physique pour vaincre la fatigue liée à Parkinson !on 17 janvier 2025
L’activité physique pour vaincre la fatigue liée à Parkinson ! La fatigue fait partie des symptômes non-moteurs les plus fréquents de la maladie de Parkinson. Invisible […]
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