Description
Parkinson et parkinsonismes
- First trial group gets commercial formulation of Parkinson’s therapy
In a trial milestone, participants in the third patient group of the ASPIRO Phase 1/2a study (NCT06344026) are now receiving the commercial formulation of ANPD001, Aspen Neuroscience’s cell therapy […]
- Study ties age at Parkinson’s diagnosis to brain amyloid buildup
People diagnosed with Parkinson’s disease in their 80s were significantly more likely to show evidence of brain buildup of amyloid-beta, a protein linked to cognitive decline in Alzheimer’s […]
- Staying active in hospital speeds recovery, improves outcomes
People with Parkinson’s disease who stay active while in the hospital may recover faster and live longer, according to a study. The research, conducted by the Parkinson’s Foundation in […]
- Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder
Alzheimers Dement. 2025 Sep;21(9):e70570. doi: 10.1002/alz.70570.ABSTRACTINTRODUCTION: Most individuals with isolated rapid eye movement sleep behavior disorder (iRBD) develop dementia with Lewy […]
- Genome-wide association study of REM sleep behavior disorder in Parkinson's disease
NPJ Parkinsons Dis. 2025 Sep 25;11(1):272. doi: 10.1038/s41531-025-01078-w.ABSTRACTREM sleep behavior disorder (RBD), is a prodromal synucleinopathy affecting a subset of Parkinson's disease (PD) […]
- Beyond the brain: The colorectal impact of Parkinson's disease
J Parkinsons Dis. 2025 Sep 24:1877718X251380261. doi: 10.1177/1877718X251380261. Online ahead of print.ABSTRACTParkinson's disease (PD) is a rapidly developing neurodegenerative disorder […]
- Apathy linked to higher amyloid burden and cognitive deterioration in Parkinson's disease
J Parkinsons Dis. 2025 Sep 17:1877718X251370969. doi: 10.1177/1877718X251370969. Online ahead of print.ABSTRACTBackgroundApathy, defined as a quantitative reduction in goal-directed activity, is a […]
- Prevention of cognitive impairment and dementia in people with Parkinson's disease: A call-to-action
J Parkinsons Dis. 2025 Oct 1:1877718X251365769. doi: 10.1177/1877718X251365769. Online ahead of print.ABSTRACTMild cognitive impairment and dementia are common symptoms in people with Parkinson's […]
- Clinical Insight on "Association Between Stress Hyperglycemia Ratio and Parkinson's Disease Across Different Glucose Metabolism Statuses-A Prospective Study From UK Biobank"
Eur J Neurol. 2025 Aug;32(8):e70340. doi: 10.1111/ene.70340.NO ABSTRACTPMID:40838419 | DOI:10.1111/ene.70340
- Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation
Alzheimers Res Ther. 2025 Aug 23;17(1):199. doi: 10.1186/s13195-025-01828-1.ABSTRACTDementia with Lewy bodies (DLB) is marked by multidomain cognitive impairments, with fluctuations in cognition and […]
Traitements pharmacologiques
Médicaments
- Acute Pharmacodynamic Effects of Oral Levodopa on Blood Pressure in Parkinson's Disease
Pharmacotherapy. 2025 Oct 1. doi: 10.1002/phar.70066. Online ahead of print.ABSTRACTBACKGROUND: Levodopa decreases blood pressure (BP) in persons with Parkinson's disease (PwP), but no […]
- Pharmacological Profiling of Thiamet-G inhibitor in MPTP induced Parkinson's Disease: Evidence from Behavioral, Biochemical, and Histological Studies
Behav Brain Res. 2025 Sep 17:115840. doi: 10.1016/j.bbr.2025.115840. Online ahead of print.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disease marked by the loss of […]
- A Novel Network Pharmacology Strategy for Retrieving a Key Functional Component Group and Mechanisms in the Di-Huang-Yin-Zi Treatment of Parkinson's Disease
Curr Neuropharmacol. 2025 Oct 2. doi: 10.2174/011570159X378077250822115218. Online ahead of print.ABSTRACTINTRODUCTION: Parkinson's Disease (PD) is a common and difficult-to-cure chronic […]
- Transcranial Direct Current Stimulation in Parkinson's Disease Patients in the Off State: A Randomized Controlled Crossover Trial Examining the Effects on Pain With and Without the Influence of Dopaminergic Medication
Pain Pract. 2025 Nov;25(8):e70082. doi: 10.1111/papr.70082.ABSTRACTBACKGROUND: tDCS has demonstrated hypoalgesic effects on Parkinson's disease (PD)-related pain applied in the On state but not in […]
- Development and Acceptability Testing of a Patient Decision Aid on Levodopa Intestinal Gel for Parkinson Disease
MDM Policy Pract. 2025 Sep 10;10(2):23814683251364883. doi: 10.1177/23814683251364883. eCollection 2025 Jul-Dec.ABSTRACTBACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease […]
Études cliniques phase 3 et phase 4
- Improvement in Motor Consistency and Stability with Foslevodopa/Foscarbidopa in Advanced Parkinson's Disease: Post Hoc Analysis of Two Phase 3 Clinical Trials
Neurol Ther. 2025 Oct 4. doi: 10.1007/s40120-025-00827-6. Online ahead of print.ABSTRACTINTRODUCTION: People with advanced Parkinson's disease (aPD) frequently experience unpredictable "Off" time and […]
- Incretin Hormones GLP-1 and GIP Normalize Energy Utilization and Reduce Inflammation in the Brain in Alzheimer's Disease and Parkinson's Disease: From Repurposed GLP-1 Receptor Agonists to Novel Dual GLP-1/GIP Receptor Agonists as Potential Disease-Modifying Therapies
CNS Drugs. 2025 Sep 12. doi: 10.1007/s40263-025-01226-z. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson's disease (PD) are chronic neurodegenerative disorders with few effective […]
- Advances in Neurodegenerative Disease Therapy: Stem Cell Clinical Trials and Promise of Engineered Exosomes
CNS Neurosci Ther. 2025 Sep;31(9):e70577. doi: 10.1111/cns.70577.ABSTRACTAIM: This review provides a systematic evaluation of 94 stem cell clinical trials to treat neurodegenerative diseases, […]
- Cognitive outcomes of deep brain stimulation depend on age and hippocampal connectivity in Parkinson's and Alzheimer's disease
Alzheimers Dement. 2025 Aug;21(8):e70498. doi: 10.1002/alz.70498.ABSTRACTINTRODUCTION: Here we contrast cognitive outcomes of deep brain stimulation (DBS) in Parkinson's disease (PD) with Alzheimer's […]
- Montelukast alleviates neuroinflammation and improves motor functions in the line 61 model of Parkinson's disease: An exploratory study
Neurotherapeutics. 2025 Jul 31:e00690. doi: 10.1016/j.neurot.2025.e00690. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative movement disorder of high global burden. […]
Traitements non pharmacologiques
Chirurgie
- Outcomes after spinal deformity surgery in patients with Parkinson's Disease: a propensity matched analysis
J Clin Neurosci. 2025 Sep 25;142:111630. doi: 10.1016/j.jocn.2025.111630. Online ahead of print.ABSTRACTAdult spinal deformity remains a complex challenge with medical and surgical complication rates […]
- Preoperative Functional Connectivity Predicts Antiparkinson Drug Change after Deep Brain Stimulation
Mov Disord. 2025 Sep 24. doi: 10.1002/mds.70063. Online ahead of print.ABSTRACTBACKGROUND: Deep brain stimulation (DBS) can effectively ameliorate motor symptoms in Parkinson's disease (PD), but […]
- Non-invasive brain stimulation: current and future applications in neurology
Nat Rev Neurol. 2025 Sep 16. doi: 10.1038/s41582-025-01137-z. Online ahead of print.ABSTRACTDevice-based non-invasive brain stimulation (NIBS) techniques show promise for the treatment of […]
- Efficacy of non-invasive brain stimulation on theory of mind and emotion processing in neuropsychiatric disorders: a systematic review and meta-analysis
Neurosci Biobehav Rev. 2025 Sep 22:106380. doi: 10.1016/j.neubiorev.2025.106380. Online ahead of print.ABSTRACTSocial cognitive impairments, including emotion processing (EP) and theory of mind […]
- Deep brain stimulation for Parkinson's disease: systematic review with meta-analysis and trial sequential analysis
BMJ Med. 2024 Aug 16;3(1):e000705. doi: 10.1136/bmjmed-2023-000705. eCollection 2024.ABSTRACTOBJECTIVE: To assess the benefits and harms of deep brain stimulation for Parkinson's disease.DESIGN: […]
Approches multidisciplinaires
- The effect of kinesiophobia on motor symptoms in individuals with Parkinson's Disease
Ir J Med Sci. 2025 Sep 30. doi: 10.1007/s11845-025-04103-2. Online ahead of print.ABSTRACTBACKGROUND: Parkinson's Disease (PD) is characterized by motor and non-motor symptoms that impair balance, […]
- Psychotherapy with a Caregiver of a Spouse with Parkinson's Disease: Integrating Systems and Individual Approaches
Clin Case Stud. 2025 Feb;24(1):21-37. doi: 10.1177/15346501241289148. Epub 2024 Sep 26.ABSTRACTFamily caregivers of persons with neurocognitive disorders sometimes experience heightened emotional […]
- An Interdisciplinary Approach to Assistive Technology for Parkinson's Disease Dementia
Clin Interv Aging. 2025 Aug 15;20:1253-1265. doi: 10.2147/CIA.S516786. eCollection 2025.ABSTRACTParkinson's Disease Dementia (PDD) and Parkinson's Disease-Mild Cognitive Impairment (PD-MCI) are […]
- Multidisciplinary inpatient care for Parkinson's disease: a single-centre cohort study on improvements in gait, overall motor function, and quality of life
Neurol Res Pract. 2025 Sep 2;7(1):62. doi: 10.1186/s42466-025-00422-y.ABSTRACTBACKGROUND: Parkinson's disease (PD) multimodal complex treatment (PD-MCT) is an inpatient therapeutic programme […]
- Effects of exercise modality-dose combinations on cognitive function in Parkinson's Disease: A bayesian dose-response systematic review and meta-analysis
Arch Gerontol Geriatr. 2025 Aug 19;139:105996. doi: 10.1016/j.archger.2025.105996. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to identify the most effective exercise modalities and […]
Thérapies alternatives
- A longitudinal study on physical activity in early Parkinson's disease
J Parkinsons Dis. 2025 Oct 3:1877718X251380487. doi: 10.1177/1877718X251380487. Online ahead of print.ABSTRACTPhysical activity (PA) remains critical in the slowing of disease progression in early […]
- Impairment in the behavioral control of body sway, gaze shift, and mental workload in Parkinson's disease
Sci Rep. 2025 Aug 19;15(1):30354. doi: 10.1038/s41598-025-12878-8.ABSTRACTWe tested Parkinson's disease (PD)-related impairments in the relationship between gaze shifts, body sway and mental workload […]
- Physical exercise modulates plasma irisin levels in endurance athletes: Implications for Parkinson's disease
Neurobiol Dis. 2025 Aug 23:107065. doi: 10.1016/j.nbd.2025.107065. Online ahead of print.ABSTRACTPhysical exercise (PE) improves clinical outcomes in individuals with Parkinson's disease (PD) through […]
- Minimal clinically important difference and substantial clinical benefits for single- and dual-task timed up and go test following motor-cognitive training in Parkinson's disease
Age Ageing. 2025 Aug 29;54(9):afaf241. doi: 10.1093/ageing/afaf241.ABSTRACTOBJECTIVE: To establish substantial clinical benefits (SCB) and minimal clinically important differences (MCIDs) for both […]
- New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson's disease
NPJ Parkinsons Dis. 2025 Aug 23;11(1):256. doi: 10.1038/s41531-025-01113-w.ABSTRACTExercise offers neuroprotective benefits in Parkinson's disease (PD) by enhancing neurotrophic factors (e.g., BDNF, […]
Qualité de vie des patients
Expérience patient
- Gender differences in depression, anxiety, and quality of life in Parkinson's disease before and after deep brain stimulation surgery: a multicentre cohort study
BMJ Neurol Open. 2025 Sep 30;7(2):e001246. doi: 10.1136/bmjno-2025-001246. eCollection 2025.ABSTRACTBACKGROUND: Disproportionately fewer females with Parkinson's disease (PD) undergo deep brain […]
- Review of the Effects of Lifestyle Modification on Parkinson's Disease
Am J Lifestyle Med. 2025 Oct 3:15598276251384591. doi: 10.1177/15598276251384591. Online ahead of print.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disorder characterized by […]
- How family caregivers adapt to Lewy body disease - tracking family caregivers' perceptions of their caregiving relationships
Geriatr Psychol Neuropsychiatr Vieil. 2025 Sep 1;23(3):331-339. doi: 10.1684/pnv.2025.1247.ABSTRACTThis one-year longitudinal study examined the relationship between caregivers' perceptions of their […]
- Advice to people with Parkinson's in my clinic: How to manage running-induced dystonia
J Parkinsons Dis. 2025 Sep 26:1877718X251372786. doi: 10.1177/1877718X251372786. Online ahead of print.ABSTRACTExercise is an essential part of the treatment of Parkinson's disease. However, certain […]
- PARKinSOUND: Impact of participation in an orchestra in patients with Parkinson's disease
J Parkinsons Dis. 2025 Oct 3:1877718X251381089. doi: 10.1177/1877718X251381089. Online ahead of print.ABSTRACTMusic therapy has emerged as a promising complementary intervention for Parkinson's […]
Technologies de soutien
- Efficacy and feasibility of virtual reality-based cognitive tele-rehabilitation in Parkinson's disease: A pilot randomized controlled trial on patients and caregivers
Digit Health. 2025 Sep 25;11:20552076251376534. doi: 10.1177/20552076251376534. eCollection 2025 Jan-Dec.ABSTRACTOBJECTIVE: Parkinson's disease (PD) is a progressive neurodegenerative disorder that […]
- Cognitive stimulation in Parkinson's disease with mild cognitive impairment
J Neurol. 2025 Sep 27;272(10):658. doi: 10.1007/s00415-025-13374-9.ABSTRACTBACKGROUND: Cognitive impairment is among the most frequent and disabling non-motor symptoms of Parkinson's disease (PD), […]
- The Views of Healthcare Professionals on iFall, a Smartphone Application for Falls Reporting in Parkinson's Disease: A Qualitative Study - PubMed
Figure 2. Themes and subthemes of the… Figure 2. Themes and subthemes of the study.
- Evaluating a digital mental health intervention for people with Parkinson's (PACT): acceptability and feasibility randomised controlled trial - PubMed
Objectives: We developed a web application (PACT app) based on Acceptance and Commitment Therapy to support mental health for people with Parkinson's. Here, we assess the app's acceptability and the […]
- Telehealth versus face-to-face delivery of speech language pathology services: A systematic review and meta-analysis - PubMed
BackgroundThere is an increasing demand for the provision of speech language pathology (SLP) services via telehealth. Therefore, we systematically reviewed randomized controlled trials comparing […]
Associations et ordres professionnels
Québec
- Photos from Parkinson Québec's poston 7 octobre 2025
🧬 Nouvelle Rubrique Scientifique! L’art comme moyen d’expression pour les personnes atteintes de la maladie de Parkinson ➡️ Bon à savoir pour agir efficacement ! Il existe […]
- The Park Run 2025on 7 octobre 2025
✨ Merci pour votre générosité et votre engagement ! ✨ Les frères Pierre-Olivier et Philippe Pigeon ont organisé, en l’honneur de leur maman, la 6e édition du Park Run le 28 septembre […]
- Merci à tous les participants du Marathon Beneva de Montréal qui, du 19 au 21 septembre prochain, vont courir pour soutenir Park...on 6 octobre 2025
Merci à tous les participants du Marathon Beneva de Montréal qui, du 19 au 21 septembre prochain, vont courir pour soutenir Parkinson Québec ! 🏃♂️💙 Un immense bravo et merci à […]
- Vivre avec le Parkinson quand on est une femmeon 6 octobre 2025
🎥 Rediffusion disponible ! Parkinson Montreal-Laval vous invite à (re)découvrir son webinaire : « Vivre avec le Parkinson quand on est une femme », présenté par la Dre Isabelle Beaulieu […]
- 📣 Vous avez manqué notre premier webinaire scientifique de la rentrée ?on 6 octobre 2025
📣 Vous avez manqué notre premier webinaire scientifique de la rentrée ? La rediffusion est déjà en ligne sur notre chaîne Youtube ! ➡️ https://youtu.be/St0oRgi7AlQ
- 🔎 Appel à participation – Projet de recherche sur la maladie de Parkinsonon 6 octobre 2025
🔎 Appel à participation – Projet de recherche sur la maladie de Parkinson L’Université d’Ottawa recrute des participants pour une étude innovante : « eCONSULT+ : Téléconsultations […]
- 🎒 Appel à bénévoles – Trek Parkinson à Charlevoix !on 5 septembre 2025
🎒 Appel à bénévoles – Trek Parkinson à Charlevoix ! Du 24 au 28 septembre, Parkinson Québec organise un trek inoubliable à Charlevoix… et nous avons besoin de vous ! Nous sommes à […]
- 🔎 Appel à participation – Projet de recherche sur la maladie de Parkinsonon 5 septembre 2025
🔎 Appel à participation – Projet de recherche sur la maladie de Parkinson L’Université d’Ottawa recrute des participants pour une étude innovante : « eCONSULT+ : Téléconsultations […]
Canada
- Un héritage d’innovation : Lancement du Fonds Kanta Marwah pour la recherche et l’innovationon 6 octobre 2025
Fonds d’innovation pour la recherche Kanta Marwah Depuis les années 1980, Parkinson Canada est à l’avant-garde de la recherche sur la maladie de Parkinson sous toutes ses formes. Nous avons […]
- Une marche pas comme les autres : la Grande Randonnée 2025 unit les Canadiens autour de la maladie de Parkinsonon 6 octobre 2025
Le week-end dernier, des communautés de tout le Canada se sont réunies pour la 2025e Grande Randonnée de Parkinson Canada, un événement national empreint d’optimisme et du pouvoir de la […]
- Wellness Wednesday: The Social Side of Aging: Why Relationships Matter for Health — BC Brain Wellness Programon 25 septembre 2025
Dr. Theresa Pauly is an Assistant Professor in Gerontology at Simon Fraser University and holds a Canada Research Chair in Social Relationships, Health, and Aging. Dr. Pauly earned her PhD in […]
- The Science of Doing Nothing: How the Default Mode Network Helps You Rechargeon 5 septembre 2025
By David KuaAugust 15th is National Relaxation Day!Our ‘hustle culture’ often values productivity and accomplishments. While chasing goals and getting things done can feel rewarding, being in […]
États-Unis
- Science News: Staying Active in the Hospital Yields Big Benefitson 6 octobre 2025
- Abbvie asks FDA to approve tavapadon as Parkinson’s treatmenton 6 octobre 2025
- Imaging can predict Parkinson’s from REM sleep behavior disorderon 6 octobre 2025
- Parkinson’s gene therapy AB-1005 trial moves forward in Europeon 6 octobre 2025
- We need to challenge the current Parkinson’s disease modelson 6 octobre 2025
- Protein clumps linked to Parkinson’s form pores in brain cells: Studyon 6 octobre 2025
- Finding hope and healing in the sounds of musicon 6 octobre 2025
- Scientists caution on some experimental Parkinson’s therapieson 6 octobre 2025
- Lifestyle Strategies to Boost Brain Health (Ask the MD Video)on 6 octobre 2025
- What’s trending in the Parkinson's Disease community?on 6 octobre 2025
International
- Publication de la Stratégie nationale MND : une étape décisive pour les personnes atteintes de maladies neurodégénérativeson 7 octobre 2025
France Parkinson salue la publication, attendue depuis plusieurs années, de la Stratégie nationale MND : une avancée majeure pour l’amélioration du parcours de soins mais aussi du parcours de […]
- Tips for Parkinson’s carers: Looking after your backon 6 octobre 2025
As a Parkinson’s carer, how can you make sure you are looking after yourself well? Caring for someone with Parkinson’s can often put a lot of strain on you physically, so looking after your back […]
- Parkinson’s and the workplace: what are reasonable adjustments at work?on 6 octobre 2025
What are reasonable adjustments at work? Do I have to tell my boss about my Parkinson’s diagnosis? Have you ever wondered exactly what Europe-wide rules are in place to protect and support people […]
- 10 of the best Parkinson’s Life Podcast episodeson 6 octobre 2025
As we celebrate a full decade of Parkinson’s Life, it’s time to highlight some of the very best Parkinson’s podcast episodes we have created for the Parkinson’s community. Our podcast has […]
- 10 delicious recipes for people with Parkinson’son 5 septembre 2025
It is well known that a balanced, nutritious diet can have a hugely positive impact on people with Parkinson’s. For 10 years, Parkinson’s Life has shared a range of […]
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