Description
Parkinson et parkinsonismes
- Deep learning-enabled accurate assessment of gait impairments in Parkinson's disease using smartphone videos
NPJ Digit Med. 2025 Dec 13. doi: 10.1038/s41746-025-02150-8. Online ahead of print.ABSTRACTGait impairments are among the most prevalent and disabling symptoms in Parkinson's Disease (PD), featuring […]
- Lack of Association Between G6PD Variants and Parkinson's Disease
HGG Adv. 2025 Dec 9:100555. doi: 10.1016/j.xhgg.2025.100555. Online ahead of print.ABSTRACTOxidative stress has been implicated in Parkinson's disease (PD). Genes involved in PD, such as PRKN, PINK1 […]
- Economic value of AI-based MRI triage for Parkinson's disease: a cost-benefit study in South Korea and the United States
Front Public Health. 2025 Dec 18;13:1723829. doi: 10.3389/fpubh.2025.1723829. eCollection 2025.ABSTRACTBACKGROUND: Early and accurate diagnosis of Parkinson's disease (PD) remains a major clinical […]
- EEG classification for neurological disorders using frequency band deciles
Sci Rep. 2025 Dec 22;15(1):45142. doi: 10.1038/s41598-025-33535-0.ABSTRACTElectroencephalography (EEG) is a widely used non-invasive technique for monitoring brain activity, offering valuable […]
- The Utility of Olfactory Testing to Discriminate Parkinson's Disease From Diagnostic Mimics: A Systematic Review and Meta-Analysis
Eur J Neurol. 2026 Jan;33(1):e70473. doi: 10.1111/ene.70473.ABSTRACTBACKGROUND: Hyposmia is present in most patients with Parkinson's disease (PD), whereas olfaction is usually preserved in its […]
- Revisiting the 2015 MDS diagnostic criteria for Parkinson disease: insights from autopsy-confirmed cases
NPJ Parkinsons Dis. 2025 Dec 13. doi: 10.1038/s41531-025-01206-6. Online ahead of print.ABSTRACTThe 2015 International Parkinson and Movement Disorder Society (MDS) Diagnostic criteria for Parkinson […]
- Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson's disease
Commun Med (Lond). 2026 Jan 3. doi: 10.1038/s43856-025-01330-7. Online ahead of print.ABSTRACTBACKGROUND: Pathogenic LRRK2 gene variants are a major genetic risk factor for both familial and sporadic […]
- No evidence for genetic role of the tumor necrosis factor pathway in Parkinson's disease
NPJ Parkinsons Dis. 2025 Dec 9;11(1):352. doi: 10.1038/s41531-025-01197-4.ABSTRACTTumor necrosis factor (TNF) inhibition is under investigation as a therapeutic strategy for Parkinson's disease (PD) […]
- The future of clinical trials? Monitoring mobility as an outcome measure in Parkinson's disease: The mobilise-D study
J Parkinsons Dis. 2025 Dec 26:1877718X251407026. doi: 10.1177/1877718X251407026. Online ahead of print.ABSTRACTBackgroundA key challenge in trials targeting disease modification in Parkinson's […]
- Evaluation and management of male sexual dysfunction in Parkinson's disease: A clinical road map
J Parkinsons Dis. 2025 Nov 28:1877718X251394341. doi: 10.1177/1877718X251394341. Online ahead of print.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disease with multiple […]
Traitements pharmacologiques
Médicaments
- Ezetimibe mitigates microglial activation in Parkinson's disease via TLR4/JNK pathway inhibition: evidence from network pharmacology and experimental validation
Brain Res. 2025 Dec 17:150116. doi: 10.1016/j.brainres.2025.150116. Online ahead of print.ABSTRACTOBJECTIVE: Neuroinflammation driven by microglial hyperactivation plays a critical role in […]
- Medication Knowledge of Patients with Parkinson's Disease: Strengths and Gaps
Mov Disord Clin Pract. 2025 Dec 9. doi: 10.1002/mdc3.70466. Online ahead of print.ABSTRACTBACKGROUND: Effective drug treatment of motor and non-motor symptoms in Parkinson's disease (PD) often […]
- Zonisamide-induced pleural effusion and agranulocytosis: a case report of a rare adverse reaction
Neurol Sci. 2026 Jan 3;47(1):89. doi: 10.1007/s10072-025-08593-x.ABSTRACTA 69-year-old woman with Parkinson's disease (Hoehn and Yahr stage 1.0) developed dyspnea and fever five weeks after […]
- Sleep disorders in Parkinson's disease: evaluating pharmacological treatments through systematic review and meta-analysis
BMC Neurol. 2025 Dec 15;25(1):504. doi: 10.1186/s12883-025-04526-5.ABSTRACTSleep disorders are the most common non-motor symptoms in patients with Parkinson's disease (PD) and can significantly […]
- The Pharmacokinetics, Pharmacological Mechanisms and Clinical Application of Zhenwu Decoction
Basic Clin Pharmacol Toxicol. 2026 Jan;138(1):e70174. doi: 10.1111/bcpt.70174.ABSTRACTZhenwu Decoction (ZWD) is a classical formula that has been used for centuries and has the effect of warming yang […]
Études cliniques phase 3 et phase 4
- Prospective Randomized Controlled Trial of the Impact of Olfactory Training on Cognitive and Emotional Function in Individuals with Parkinson Disease
Arch Rehabil Res Clin Transl. 2025 Jul 24;7(4):100497. doi: 10.1016/j.arrct.2025.100497. eCollection 2025 Dec.ABSTRACTOBJECTIVE: To investigate the clinical effects of olfactory training (OT) on […]
- Foslevodopa/Foscarbidopa in Younger Patients Earlier Within Advanced Parkinson's Disease: Post Hoc Analysis of a Randomized Trial
Neurol Ther. 2025 Dec 1. doi: 10.1007/s40120-025-00856-1. Online ahead of print.ABSTRACTINTRODUCTION: We evaluated continuous subcutaneously administered foslevodopa/foscarbidopa (LDp/CDp) in younger […]
- Advances in Neurological Therapies: A Review of Clinical Trials in Alzheimer's, Parkinson's, and Multiple Sclerosis
Am J Med. 2025 Nov 27:S0002-9343(25)00826-5. doi: 10.1016/j.amjmed.2025.11.025. Online ahead of print.ABSTRACTThe period from 2020 to 2025 marked a pivotal juncture in the treatment of major […]
- Constructing a Personalized Treatment Rule for Initial Therapy in Early Parkinson's Disease
Pharmacotherapy. 2025 Nov 28. doi: 10.1002/phar.70069. Online ahead of print.ABSTRACTBACKGROUND: Dopaminergic therapies such as levodopa and dopamine receptor agonists (DRA) improve motor function in […]
- Safety and efficacy of pimavanserin in patients with Lewy body dementia experiencing dementia-related psychosis in the HARMONY study
BMC Neurol. 2025 Nov 24;25(1):479. doi: 10.1186/s12883-025-04496-8.ABSTRACTBACKGROUND: Pimavanserin is approved by the US Food and Drug Administration for the treatment of hallucinations and […]
Traitements non pharmacologiques
Chirurgie
- Long-term globus pallidus internus deep brain stimulation in a young patient with spinocerebellar ataxia type 3 initially presenting with levodopa-responsive parkinsonism: a 6-year follow-up case report and literature review
Ther Adv Neurol Disord. 2025 Dec 16;18:17562864251396525. doi: 10.1177/17562864251396525. eCollection 2025.ABSTRACTSpinocerebellar ataxia type 3 (SCA3) is an inherited neurodegenerative disorder. […]
- Deep brain stimulation and magnetic resonance-guided focused ultrasound in Parkinsonism and related disorders: State-of-the-Art and future prospects
J Formos Med Assoc. 2025 Dec 10:S0929-6646(25)00658-8. doi: 10.1016/j.jfma.2025.12.014. Online ahead of print.ABSTRACTDeep brain stimulation (DBS) has been a cornerstone treatment for […]
- A brief history of electrical brain stimulation in humans
Neurophysiol Clin. 2025 Dec 5;56(1):103123. doi: 10.1016/j.neucli.2025.103123. Online ahead of print.ABSTRACTThe concept of cerebral localization originated from cerebral electrical stimulation. […]
- Effects of Deep Brain Stimulation and Botulinum Toxin to Manage Pisa Syndrome in Parkinson's Disease
Mov Disord Clin Pract. 2025 Dec 4. doi: 10.1002/mdc3.70469. Online ahead of print.ABSTRACTBACKGROUND: Pisa Syndrome (PS) is an abnormal postural deformity characterized by lateral trunk flexion […]
- Deep Brain Stimulation: Mechanisms, Cost-Effectiveness, and Precision Applications Across Neurology and Psychiatry
Biomedicines. 2025 Nov 1;13(11):2691. doi: 10.3390/biomedicines13112691.ABSTRACTIn less than 30 years, Deep Brain Stimulation (DBS) has evolved from an antiparkinsonian rescue intervention into a […]
Approches multidisciplinaires
- Upper Limb Exercises Reduce Non-motor Symptoms and Increase Cognitive Function in Parkinson's Disease: Randomized Controlled Trial
J Geriatr Psychiatry Neurol. 2025 Dec 26:8919887251409414. doi: 10.1177/08919887251409414. Online ahead of print.ABSTRACTBackgroundPhysical exercise is a promising approach to address non-motor […]
- Telepsychotherapy Improves Health-Related Quality of Life in Parkinson's Disease
Am J Geriatr Psychiatry. 2025 Nov 22:S1064-7481(25)00529-9. doi: 10.1016/j.jagp.2025.11.010. Online ahead of print.ABSTRACTOBJECTIVES: Parkinson's disease (PD) is associated with significant […]
- Yi Jin Jing Exercise Program Improves in Cognition, Sleep and Functional Mobility for Mild and Moderate Parkinson 's Disease: A Randomized Controlled Trial
Exp Aging Res. 2025 Dec 13:1-16. doi: 10.1080/0361073X.2025.2599036. Online ahead of print.ABSTRACTBACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder of the basal ganglia that […]
- Reducing caregiver burden in advanced Parkinson's disease through targeted training: A longitudinal study with dose-response modeling
Parkinsonism Relat Disord. 2025 Dec 1;142:108137. doi: 10.1016/j.parkreldis.2025.108137. Online ahead of print.ABSTRACTBACKGROUND: Family caregivers of people with advanced Parkinson's disease (PD) […]
- Non-Pharmacological and Non-Surgical Management of Parkinson's Disease: A Systematic Review of Clinical Practice Guidelines
Mov Disord Clin Pract. 2025 Dec 26. doi: 10.1002/mdc3.70453. Online ahead of print.ABSTRACTBACKGROUND: Non-pharmacological and non-surgical interventions from nursing and allied health professionals […]
Thérapies alternatives
- Cardiovascular exercise enhances motor learning across multiple sessions in people with Parkinson's disease: a randomized controlled pilot trial
NPJ Sci Learn. 2025 Dec 23. doi: 10.1038/s41539-025-00391-6. Online ahead of print.ABSTRACTMotor learning is critical for effective motor rehabilitation, yet impaired in people with Parkinson's […]
- Compliance and Satisfaction for 16 months of Adapted Tango vs. Supervised Walking for People with Parkinson's
NPJ Parkinsons Dis. 2025 Dec 26. doi: 10.1038/s41531-025-01220-8. Online ahead of print.ABSTRACTThe present study is an exploratory secondary analysis examining associations between Parkinson's […]
- Group singing through the lens of polyvagal theory: A pilot study in patients with Parkinson's disease
PLoS One. 2025 Dec 30;20(12):e0337210. doi: 10.1371/journal.pone.0337210. eCollection 2025.ABSTRACTThere is a need to counteract the chronic progression of Parkinson's disease (PD). This complex […]
- Self-delivered arousal-heightening stimuli to improve mobility in persons with parkinsonism: A case series
J Parkinsons Dis. 2025 Dec 22:1877718X251409029. doi: 10.1177/1877718X251409029. Online ahead of print.ABSTRACTClassic accounts of 'kinesia paradoxa' typically involve highly stressful or […]
- Effects of Ketogenic Diet on Quality of Life in Parkinson Disease: An Integrative Review
Nutrients. 2025 Oct 24;17(21):3343. doi: 10.3390/nu17213343.ABSTRACTBackground/Aims: Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the degeneration of dopaminergic […]
Qualité de vie des patients
Expérience patient
- It Is Personal: What People with Parkinson's Disease Say Matters Most for Quality of Life
Mov Disord. 2025 Dec 12. doi: 10.1002/mds.70134. Online ahead of print.ABSTRACTBACKGROUND: Little is known about what matters most for quality of life in people with Parkinson's disease and how much […]
- A small-scale study on dancing for people living with Parkinson's disease
PLoS One. 2025 Dec 12;20(12):e0335433. doi: 10.1371/journal.pone.0335433. eCollection 2025.ABSTRACTBACKGROUND: People with Parkinson's disease (PD) need life-long rehabilitative interventions to slow […]
- A mixed-methods study to explore the modifiable aspects of treatment burden in Parkinson's disease and develop recommendations for improvement
PLoS One. 2025 Dec 15;20(12):e0338620. doi: 10.1371/journal.pone.0338620. eCollection 2025.ABSTRACTBACKGROUND: People with Parkinson's (PwP) and their caregivers have to manage multiple daily […]
- Depending on intensity, exercise improved or worsened pathology in a model of prodromal Parkinson's disease
NPJ Parkinsons Dis. 2025 Nov 23. doi: 10.1038/s41531-025-01200-y. Online ahead of print.ABSTRACTExercise is increasingly applied as non-pharmacological intervention in Parkinson's disease (PD). While […]
- Self-Care Experiences and Behaviours in People With Parkinson's Disease: A Meta-Synthesis
J Geriatr Psychiatry Neurol. 2025 Nov 13:8919887251392139. doi: 10.1177/08919887251392139. Online ahead of print.ABSTRACTBackgroundParkinson's disease (PD) is the fastest-growing neurodegenerative […]
Technologies de soutien
- Home-Based Augmented Reality Gait-and-Balance Therapy in Parkinson's Disease: An examination of exercise intensity
Arch Phys Med Rehabil. 2025 Dec 29:S0003-9993(25)01121-9. doi: 10.1016/j.apmr.2025.12.008. Online ahead of print.ABSTRACTOBJECTIVE: Our objectives to examine whether Strolll - an […]
- PDWearML: Leveraging Daily Activities for Fast Parkinson's Disease Severity Assessment with Wearable Machine Learning
IEEE Trans Biomed Eng. 2025 Dec 25;PP. doi: 10.1109/TBME.2025.3648564. Online ahead of print.ABSTRACTOBJECTIVE: Achieving effective and robust free-living PD severity assessment with wearable […]
- An online platform to increase access to gait rehabilitation for underserved Parkinson's disease communities
J Parkinsons Dis. 2025 Dec 30:1877718X251410104. doi: 10.1177/1877718X251410104. Online ahead of print.ABSTRACTCompensation strategies are a key element of gait rehabilitation in Parkinson's disease, […]
- Effects of Rehabilitative Device on Parkinsonian Gait
Int J Exerc Sci. 2025 Dec 1;18(7):1422-1439. eCollection 2025.ABSTRACTParkinson's disease (PD) is second in occurrence among neurodegenerative disorders after Alzheimer's disease and significantly […]
- Digital health in presymptomatic diseases
Rev Neurol (Paris). 2025 Nov;181(9):937-943. doi: 10.1016/j.neurol.2025.06.017. Epub 2025 Nov 12.ABSTRACTMost of widely available consumer devices like smartphones and tablets are equipped with […]
Associations et ordres professionnels
Québec
- ⚖️ Aide médicale à mourir : mises à jour et clarificationson 5 janvier 2026
⚖️ Aide médicale à mourir : mises à jour et clarifications Parkinson Québec, en partenariat avec l’AQDMD, vous invite à un webinaire essentiel pour mieux comprendre les récentes […]
- ⏳ Compte à rebours lancé : les places sont limitées!on 5 janvier 2026
⏳ Compte à rebours lancé : les places sont limitées! Il reste encore du temps, mais plus beaucoup de places. Si vous rêvez de vivre une aventure qui transforme, c’est le moment de […]
- 🌍 Zoom sur la destination de la seconde édition du Défi Trek : Le Sentier des Caps, dans Charlevoixon 5 janvier 2026
🌍 Zoom sur la destination de la seconde édition du Défi Trek : Le Sentier des Caps, dans Charlevoix. Un parcours immersif au cœur de paysages à couper le souffle : forêts profondes, vues […]
- La série “Sécuriser son milieu de vie” est maintenant disponible!on 5 janvier 2026
La série “Sécuriser son milieu de vie” est maintenant disponible! 💡 Au fil des semaines, nous vous avons partagé des astuces simples pour rendre chaque espace plus sécuritaire et […]
- L’inscription pour les sessions d’hiver 2026 du projet Imagerie diagnostique est ouvert !on 5 janvier 2026
L’inscription pour les sessions d’hiver 2026 du projet Imagerie diagnostique est ouvert ! Le projet Imagerie diagnostique propose de réunir des personnes atteintes de la maladie de Parkinson et […]
- 📱 La technologie au service d’une maison sécuritaireon 5 janvier 2026
📱 La technologie au service d’une maison sécuritaire 💡 Voici la sixième et dernière capsule de notre série : Sécuriser son milieu de vie. La technologie peut grandement contribuer à […]
- 🚗 Adapter la voitureon 5 janvier 2026
🚗 Adapter la voiture 💡 Voici la cinquième capsule de notre série : Sécuriser son milieu de vie. Entrer, sortir ou voyager en voiture peut parfois devenir un défi. Découvrez des […]
- Quand la maladie de Parkinson entre dans une famille, tout change : les repères, les routines, les certitudeson 5 janvier 2026
Quand la maladie de Parkinson entre dans une famille, tout change : les repères, les routines, les certitudes. Mais au cœur de cette épreuve, il reste une force qui ne faiblit jamais : l’amour. […]
Canada
- Anna D’lorio nous montre la vrai définition de la forceon 5 janvier 2026
Anna a toujours été active : la salle de sport était sa deuxième maison bien avant son diagnostic de Parkinson. Mais lorsqu’Anna a été diagnostiquée en 2017, elle savait une chose avec […]
- Récapitulatif de la conférence : Journée de la recherche sur la maladie de Parkinson dans le sud-ouest de l’Ontarioon 5 janvier 2026
Le 19 novembre 2025, Parkinson Canada a organisé la Journée de la recherche sur la maladie de Parkinson dans le sud-ouest de l’Ontario à London. L’événement a réuni des chercheurs, des […]
États-Unis
- Finding ways to make Parkinson’s hospital care more ‘age friendly’on 5 janvier 2026
The Parkinson’s Foundation has published a new journal article outlining a practical pathway for making hospital care more age friendly for older people living with Parkinson’s disease. The […]
- Companies team on bringing Parkinson’s treatments to brainon 5 janvier 2026
Biotechnology company Ophidion is teaming up with Neuronasal, a clinical-stage company focused on nose-to-brain delivery of therapies for central nervous system disorders, to develop ways to deliver […]
- Experimental vaccine shows early signs of benefit in Parkinson’son 5 janvier 2026
ACI-7104, an experimental vaccine being tested in people with early-stage Parkinson’s disease, has been generally well tolerated and is showing early signals that it may slow disease progression, […]
- New study reveals why exercise is vital for Parkinson’s brain healthon 5 janvier 2026
Aerobic exercise triggers a surge of dopamine in the brain that can significantly improve movement and coordination during the aging process, a new study in mice suggests. By providing […]
- Parkinson’s disrupts key brain connections, PET scan study findson 5 janvier 2026
People with Parkinson’s disease exhibit an interplay between the loss of dopamine-producing neurons and overall nerve cell connections, or synapses, in two key brain regions that is distinct from […]
- Top 10 Parkinson’s news stories of 2025on 5 janvier 2026
Throughout 2025, the team at Parkinson’s News Today has reported on the latest research updates and advances in care related to Parkinson’s disease. Below is a list of the top 10 most-read […]
- Trial testing Crexont for advanced Parkinson’s kicks off in Europeon 5 janvier 2026
Zambon Biotech has dosed the first patient in its clinical trial testing Crexont (IPX203) — an extended-release formulation of carbidopa/levodopa (CD/LD) that aims to ease so-called off episodes […]
- New trial offers extended buntanetap access for people with Parkinson’son 5 janvier 2026
A new study will investigate the long-term safety and effects of the experimental treatment buntanetap in people with Parkinson’s disease, according to Annovis Bio, the therapy’s developer. The […]
- Parkinson’s Disease and the Gut: Additional Questions Answeredon 5 janvier 2026
On a recent episode of APDA’s Dr. Gilbert Hosts, Dr. Gilbert spoke with Dr. Malu Gamez Tansey, the James A. Caplin, MD Chair in Alzheimer’s Disease at Indiana University School of Medicine and […]
- Constipation in Early Parkinson’s Disease is Linked to Neuroinflammationon 5 janvier 2026
Constipation in Early Parkinson’s Disease is Linked to Neuroinflammation Constipation can be a very early non-motor symptom of Parkinson’s disease (PD) often appearing long before motor […]
International
- Foods to avoid with Parkinson’s disease – dietitian-approved advice on what foods to limit and whyon 5 janvier 2026
Although diet and nutrition are well-known to be important when it comes to living well with Parkinson’s, it can tricky to work out what foods to avoid with Parkinson’s, or simply limit, and […]
- Foot exercises for Parkinson’s to do at homeon 5 janvier 2026
What are the best foot exercises for people with Parkinson’s? If you’re living with Parkinson’s, everything from a change in gait or balance problems to increasing stiffness can have an effect […]
- Global Alliance for Parkinson’s Platforms (GAPP) unites global trials leaderson 5 janvier 2026
UK-based organisation Cure Parkinson’s has united with France Parkinson to form new platform trials organisation Global Alliance for Parkinson’s Platforms (GAPP), it announced in November. GAPP […]
- “Live in the moment”: quotes from celebrities and famous people with Parkinson’s – including Michael J Fox, Superman star Valeri...on 5 janvier 2026
Live for today, make lifestyle changes, and tell people in your own time – these are some of the wise words contained in quotes from celebrities and famous people with Parkinson’s disease. […]
- EU will “do our part” to improve healthcare for people with Parkinson’s in Europe, says MEPon 5 Décembre 2025
In an important meeting with the Parkinson’s Europe board on 5 November, Croatian MEP Tomislav Sokol brought hope to the Parkinson’s community by outlining how the EU could help improve […]
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