Maladies complexes

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COVID longue

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Gut Microbial Signatures in Long COVID: Potential Biomarkers and Therapeutic Targets
on 6 juin 2025
Infect Dis Ther. 2025 Jun 1. doi: 10.1007/s40121-025-01167-6. Online ahead of print.ABSTRACTINTRODUCTION: Following severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, symptoms can persist for more than 12 weeks in over 10% of […]
The impact of long COVID on physical and cardiorespiratory parameters: A systematic review
on 6 juin 2025
PLoS One. 2025 Jun 4;20(6):e0318707. doi: 10.1371/journal.pone.0318707. eCollection 2025.ABSTRACTBACKGROUND: Since the emergence of COVID-19, millions worldwide have continued to experience persistent symptoms months after infection. Among these, […]
What Are the Barriers and Supports to a Return to Health From Long COVID? A Qualitative Study Designed, Developed, and Conducted by Individuals With Lived Experience of Long COVID
on 6 juin 2025
Qual Health Res. 2025 Jun 4:10497323251337566. doi: 10.1177/10497323251337566. Online ahead of print.ABSTRACTLong COVID is a debilitating and persistent illness that affects individuals in multiple and dynamic ways. Because of the significant […]
Preexisting symptoms increase the risk of developing long COVID during the SARS-CoV-2 pandemic
on 6 juin 2025
J Intern Med. 2025 Jun 4. doi: 10.1111/joim.20102. Online ahead of print.ABSTRACTBACKGROUND: Long COVID is defined as otherwise unexplained symptoms following a SARS-CoV-2 infection.OBJECTIVE: To examine the prevalence of preexisting symptoms […]
Association of Pre-COVID Fitness With Post-COVID Fitness and Long COVID in the Cooper Center Longitudinal Cohort Study
on 6 juin 2025
J Am Heart Assoc. 2025 May 13:e040629. doi: 10.1161/JAHA.124.040629. Online ahead of print.ABSTRACTBACKGROUND: Cross-sectional studies suggesting that SARS-CoV-2 infection and long COVID are associated with reduced cardiorespiratory fitness (CRF) […]
HIV Infection and Long COVID: A RECOVER Program, Electronic Health Record Based Cohort Study
on 6 juin 2025
Clin Infect Dis. 2025 May 12:ciaf242. doi: 10.1093/cid/ciaf242. Online ahead of print.ABSTRACTPeople with HIV may be at increased risk for long COVID after acute SARS-CoV-2 infection. We investigated the association between HIV and long COVID in two […]
Genome-wide association study of long COVID - Nature
on 6 juin 2025
Genome-wide association study of long COVID Nature
Work Productivity Loss in People Living with Long COVID Symptoms over 2 years from Infection
on 8 mai 2025
J Occup Environ Med. 2025 May 5. doi: 10.1097/JOM.0000000000003440. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the work productivity loss in people experiencing long COVID symptoms more than two years after infection.METHODS: In a […]
The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies
on 8 mai 2025
Nat Commun. 2025 May 7;16(1):4249. doi: 10.1038/s41467-025-59012-w.ABSTRACTThe global evidence on the risk of symptoms of Long Covid in general populations infected with SARS-CoV-2 compared to uninfected comparator/control populations remains […]
Mixed methods study of views and experience of non-hospitalised individuals with long COVID of using pacing interventions
on 8 mai 2025
Sci Rep. 2025 Apr 25;15(1):14467. doi: 10.1038/s41598-025-96319-6.ABSTRACTLong COVID is highly prevalent and debilitating, with key symptoms including fatigue, breathlessness, and brain fog. Pacing is an approach to energy conservation used to help […]
Social determinants of recovery from ongoing symptoms following COVID-19 in two UK longitudinal studies: a prospective cohort study
on 8 mai 2025
BMJ Public Health. 2025 Mar 20;3(1):e001166. doi: 10.1136/bmjph-2024-001166. eCollection 2025 Jan.ABSTRACTINTRODUCTION: Social gradients in COVID-19 exposure and severity have been observed internationally. Whether combinations of pre-existing […]
Development and Validation of POCOKIDS-Q-A Questionnaire to Assess Post COVID-19 Symptoms in Children
on 8 mai 2025
Acta Paediatr. 2025 Apr 13. doi: 10.1111/apa.70094. Online ahead of print.ABSTRACTAIM: To identify the symptom burden in children and adolescents with post COVID-19, a validated and reliable instrument is needed, particularly to assess symptoms and […]
A multidimensional network of factors associated with long COVID in the French population
on 8 mai 2025
Commun Med (Lond). 2025 Apr 13;5(1):114. doi: 10.1038/s43856-025-00846-2.ABSTRACTBACKGROUND: Various factors associated with long COVID have been evidenced, but the heterogeneity of definitions and epidemiological investigations has often hidden […]
Cardiovascular post-acute sequelae of SARS-CoV-2 in children and adolescents: cohort study using electronic health records
on 8 mai 2025
Nat Commun. 2025 Apr 11;16(1):3445. doi: 10.1038/s41467-025-56284-0.ABSTRACTThe risk of cardiovascular outcomes following SARS-CoV-2 infection has been reported in adults, but evidence in children and adolescents is limited. This paper assessed the […]
Considerations for Long COVID Rehabilitation in Women
on 8 mai 2025
Phys Med Rehabil Clin N Am. 2025 May;36(2):371-387. doi: 10.1016/j.pmr.2024.11.009. Epub 2024 Dec 9.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has given rise to long COVID, a prolonged manifestation of severe acute respiratory syndrome […]
Pediatric Long COVID Subphenotypes: An EHR-based study from the RECOVER program
on 8 mai 2025
PLOS Digit Health. 2025 Apr 10;4(4):e0000747. doi: 10.1371/journal.pdig.0000747. eCollection 2025 Apr.ABSTRACTPediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical […]
A long COVID researcher continues to search for answers | Harvard T.H. Chan School of Public Health
on 8 mai 2025
Beth Stelson / Photo by Kent Dayton Amid federal funding cuts for health research, the Trump administration has shuttered the Department of Health and Human Services’ (HHS) Office of Long Covid Research and Practice. Beth Stelson, postdoctoral […]
The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies - Nature
on 8 mai 2025
The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies Nature
Long COVID-19: Impact of a personalized rehabilitation program
on 31 mars 2025
Rehabilitacion (Madr). 2025 Mar 28;59(2):100903. doi: 10.1016/j.rh.2025.100903. Online ahead of print.ABSTRACTINTRODUCTION: Several guidelines have proposed specific rehabilitation programs to treat symptoms/sequelae in patients with post-acute […]
Reorganization of brain connectivity in post-COVID condition: a (18)F-FDG PET study
on 31 mars 2025
EJNMMI Res. 2025 Mar 30;15(1):28. doi: 10.1186/s13550-025-01217-7.ABSTRACTBACKGROUND: A hypometabolic brain pattern has been reported in patients with post-COVID condition (PCC). The aim of this study was to investigate reorganization in metabolic […]

COVID longue : lignes directrices canadiennes

Mise à jour du 5 mars 2025

Mise à jour du 31 mars 2025

Maladie de Lyme

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Research Substantiates Lyme Disease is Not a Psychosomatic Illness : Johns Hopkins Lyme Disease Research Center
on 6 juin 2025
Several published peer-reviewed studies conducted by the Johns Hopkins Lyme Disease Research Center are generating a growing body of evidence that Lyme disease associated persistent symptoms are biologically driven and not psychosomatic. One study, […]
Seroprevalence of Lyme Disease in Asian Human Populations: A Systematic Review and Meta-Analysis
on 6 juin 2025
Vector Borne Zoonotic Dis. 2025 May 23. doi: 10.1089/vbz.2024.0092. Online ahead of print.ABSTRACTBackground: Lyme disease (LD, also known as Lyme borreliosis) is the most frequent tick-transmitted disease caused by the spirochete Borrelia in Europe […]
Prevalence of Rheumatoid Factor and Anti-citrullinated Protein Antibodies in Patients With Post-treatment Lyme Disease
on 6 juin 2025
Cureus. 2025 Apr 18;17(4):e82541. doi: 10.7759/cureus.82541. eCollection 2025 Apr.ABSTRACTPost-treatment Lyme disease (PTLD) occurs in a portion of patients after initial antibiotic treatment of Lyme disease (LD) and is often characterized by […]
Computerised decision support system towards informing Lyme borreliosis incidence in France
on 8 mai 2025
Sci Rep. 2025 May 3;15(1):15506. doi: 10.1038/s41598-025-99896-8.ABSTRACTIn Europe, the estimation of Lyme borreliosis (LB) incidence is challenged by its heterogeneous reporting. In France, LB incidence is estimated from cases reported voluntarily […]
FACE DROPS: A Clinical Risk Assessment Tool for Differentiation of Acute Lyme Disease-Associated Facial Palsy From Bell Palsy
on 8 mai 2025
Neurol Clin Pract. 2025 Jun;15(3):e200476. doi: 10.1212/CPJ.0000000000200476. Epub 2025 Apr 18.ABSTRACTBACKGROUND AND OBJECTIVES: Facial palsy is a common manifestation of Lyme disease, accounting for up to 5% of acute facial palsies in endemic […]
Alpha-Gal Sensitization Dynamics in Individuals After Tick Bites With or Without Erythema Migrans
on 8 mai 2025
Clin Exp Allergy. 2025 Apr;55(4):350-353. doi: 10.1111/cea.70011. Epub 2025 Mar 19.ABSTRACTα-Gal syndrome (AGS) is an emerging tick-borne disease characterised by the development of specific immunoglobulin E (sIgE) antibodies against […]
Confusing variety of symptoms: Lyme carditis coinciding with Puumala hantavirus infection
on 31 mars 2025
Diagn Microbiol Infect Dis. 2025 Jun;112(2):116784. doi: 10.1016/j.diagmicrobio.2025.116784. Epub 2025 Mar 1.ABSTRACTThe temporal coincidence of a tick- and rodent-associated disease led to a confusing variety of symptoms, which posed diagnostic […]
Lower Frequency of Multiple Erythema Migrans Skin Lesions in Lyme Reinfections, Europe
on 31 mars 2025
Emerg Infect Dis. 2025 Apr;31(4):662-668. doi: 10.3201/eid3104.241329.ABSTRACTThe erythema migrans (EM) skin lesion is the most common clinical manifestation of Lyme borreliosis. Information about EM in Lyme borreliosis reinfection is limited. Of […]
UHPLC-MS/MS-based untargeted metabolite profiling of Lyme neuroborreliosis
on 31 mars 2025
Sci Rep. 2025 Mar 11;15(1):8442. doi: 10.1038/s41598-025-92189-0.ABSTRACTThe diagnosis of Lyme neuroborreliosis (LNB) requires the demonstration of intrathecal synthesis of Borrelia antibodies in a patient's cerebrospinal fluid (CSF), which involves […]
Adult-Onset Still's Disease (AOSD) in Patient with Previous Lyme Disease
on 31 mars 2025
J Brown Hosp Med. 2025 Jan 1;4(1):16-19. doi: 10.56305/001c.124992. eCollection 2025.ABSTRACTAdult-onset Still's Disease (AOSD) is a rare autoimmune disorder causing systemic inflammation that presents with a rash, fever, polyarthritis, and a […]
Borrelia spielmanii-Associated Neuroborreliosis in Patient Receiving Rituximab, Belgium
on 3 mars 2025
Emerg Infect Dis. 2025 Feb;31(2):341-344. doi: 10.3201/eid3102.240777.ABSTRACTA 58-year-old woman in Belgium with a history of follicular lymphoma treated with rituximab sought care for a rapid sensory-motor deficit. Seronegative neuroborreliosis […]
Borrelia burgdorferi serine protease HtrA is a pleiotropic regulator of stress response, motility, flagellar hemostasis, and infectivity
on 3 mars 2025
Commun Biol. 2025 Mar 1;8(1):341. doi: 10.1038/s42003-025-07781-x.ABSTRACTHigh-temperature requirement protease A (HtrA) is a family of serine proteases that regulate bacterial stress response through controlling protein quality. This report shows […]
A type-specific B-cell epitope at the apex of outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi
on 3 mars 2025
Microbiol Spectr. 2025 Feb 14:e0288324. doi: 10.1128/spectrum.02883-24. Online ahead of print.ABSTRACTBroadly protective immunity to the Lyme disease spirochete, Borreliella burgdorferi, is constrained by antibodies against type-specific epitopes on […]
Borréliose de Lyme et autres maladies vectorielles à tiques : la HAS actualise ses recommandations - Haute Autorité de Santé
on 3 mars 2025
Borréliose de Lyme et autres maladies vectorielles à tiques : la HAS actualise ses recommandations Haute Autorité de Santé
Dose Evaluation and Optimization of Amoxicillin in Children Treated for Lyme Disease
on 13 février 2025
J Clin Pharmacol. 2025 Jan 27. doi: 10.1002/jcph.6190. Online ahead of print.ABSTRACTAmoxicillin is commonly used to treat erythema migrans in the first stage of Lyme disease in children, with a recommended dose of 50 mg/kg/day, administered three […]
Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis
on 13 février 2025
Brain Behav Immun Health. 2025 Jan 2;43:100931. doi: 10.1016/j.bbih.2024.100931. eCollection 2025 Feb.ABSTRACTBACKGROUND AND OBJECTIVE: Lyme disease, caused by Borrelia burgdorferi, presents major health challenges worldwide, leading to serious […]
Lyme neuroborreliosis in Japan: Borrelia burgdorferi sensu lato as a cause of meningitis of previously undetermined etiology in hospitalized patients outside of the island of Hokkaido, 2010-2021
on 15 janvier 2025
Eur J Neurol. 2025 Jan;32(1):e70005. doi: 10.1111/ene.70005.ABSTRACTBACKGROUND AND PURPOSE: Clinical manifestations of Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl), include erythema migrans, Lyme neuroborreliosis (LNB), […]
Perspective: Incidence of Clinician-Diagnosed Lyme Disease in Manitoba, Canada 2009-2018
on 15 janvier 2025
Vector Borne Zoonotic Dis. 2025 Jan 6. doi: 10.1089/vbz.2024.0088. Online ahead of print.ABSTRACTIntroduction: Lyme disease (LD) surveillance yields useful information to monitor the disease trends and spatial distribution. However, due to several […]
Clinical characteristics and serological profiles of Lyme disease in children: a 15-year retrospective cohort study in Switzerland
on 15 janvier 2025
Lancet Reg Health Eur. 2024 Dec 9;48:101143. doi: 10.1016/j.lanepe.2024.101143. eCollection 2025 Jan.ABSTRACTBACKGROUND: Lyme disease (LD) is caused by Borrelia burgdorferi and is the most common tickborne disease in the northern hemisphere. […]
The Current and Future State of Vaccines for Lyme Disease
on 15 janvier 2025
Clin Infect Dis. 2024 Dec 23:ciae639. doi: 10.1093/cid/ciae639. Online ahead of print.ABSTRACTLyme disease is caused by Borrelia species that are transmitted by Ixodes ticks prevalent in parts of the United States and Europe. A Lyme vaccine […]

Encéphalomyélite myalgique

maladies_complexes_encephalomyelite via biblio.chum on Inoreader

Stress-Induced Changes in Immune Signatures in ME/CFS Patients Determined by Transcriptome Analysis
on 6 juin 2025
Methods Mol Biol. 2025;2920:103-112. doi: 10.1007/978-1-0716-4498-0_7.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, complex multi-organ illness characterized by unexplained debilitating fatigue and post-exertional […]
Application of DNA Methylome Analysis to Patients with ME/CFS
on 6 juin 2025
Methods Mol Biol. 2025;2920:141-160. doi: 10.1007/978-1-0716-4498-0_9.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome is a post-viral/stressor syndrome that has a complex pathophysiology reflecting multiple changes in many cell […]
Analysis of Transient Receptor Potential Ion Channels in ME/CFS
on 6 juin 2025
Methods Mol Biol. 2025;2920:83-99. doi: 10.1007/978-1-0716-4498-0_6.ABSTRACTThis chapter provides a comprehensive overview of methodologies currently employed to study ion channels, particularly transient receptor potential melastatin 3 (TRPM3) in […]
Repeated Cardiopulmonary Exercise Testing of ME/CFS Patients
on 6 juin 2025
Methods Mol Biol. 2025;2920:163-172. doi: 10.1007/978-1-0716-4498-0_10.ABSTRACTPost-exertional malaise is a cardinal symptom present in 95% of individuals with myalgic encephalomyelitis (ME/CFS). Repeated cardiopulmonary exercise testing has been […]
Quantitative Proteomics on Immune Cells of ME/CFS Patients Using SWATH-MS
on 6 juin 2025
Methods Mol Biol. 2025;2920:113-140. doi: 10.1007/978-1-0716-4498-0_8.ABSTRACTProteomics is one of the "omics" disciplines that has provided molecular insights into the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). […]
Using the Ratio of Phosphorylated to Non-phosphorylated Forms of Stress Kinase PKR as a Potential Diagnostic Test for ME/CFS
on 6 juin 2025
Methods Mol Biol. 2025;2920:13-28. doi: 10.1007/978-1-0716-4498-0_2.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness characterized by a set of mainly neurological symptoms lasting for over 6 months. Currently, […]
Causal relationship between immune cells and post-viral fatigue syndrome: a Mendelian randomization study
on 6 juin 2025
Virol J. 2025 May 30;22(1):171. doi: 10.1186/s12985-025-02809-4.ABSTRACTBACKGROUND: Accumulating evidence has hinted at a correlation between immune cells and post-viral fatigue syndrome (PVFS). However, it is still ambiguous whether these […]
Sociodemographic and psychosocial correlates of fatigue and chronic fatigue: A cross-sectional study from a South East London community survey
on 6 juin 2025
J Psychosom Res. 2025 Jun;193:112146. doi: 10.1016/j.jpsychores.2025.112146. Epub 2025 May 8.ABSTRACTOBJECTIVE: A better understanding of fatigue and chronic fatigue symptoms in the community may lead to better targeted preventative interventions. […]
Implementation of a Chronic Fatigue Syndrome (CFS) Pathway at the Living Well Partnership(LWP), Primary Care Network (PCN)
on 6 juin 2025
Br J Gen Pract. 2025 May 22;75(suppl 1):bjgp25X742149. doi: 10.3399/bjgp25X742149. Print 2025 May.ABSTRACTBACKGROUND: Evidence suggests that early identification and treatment of CFS improve patient outcomes, reduce the risk of prolonged disability, […]
The efficacy of acupuncture-based chinese medicine in chronic fatigue syndrome: A meta-analysis
on 6 juin 2025
Medicine (Baltimore). 2025 May 23;104(21):e42111. doi: 10.1097/MD.0000000000042111.ABSTRACTBACKGROUND: The efficacy of acupuncture therapy in treating chronic fatigue syndrome remains a matter of intense debate owing to contradictory findings. This […]
Multidimensional outcomes associated with chronic fatigue over 12 months in youth with emerging mood disorders
on 6 juin 2025
J Psychosom Res. 2025 Jun;193:112141. doi: 10.1016/j.jpsychores.2025.112141. Epub 2025 May 8.ABSTRACTBACKGROUND: Complaints of chronic fatigue lasting weeks or longer are common during adolescence. Little is known about factors associated with […]
HERV Dysregulation in a Case of Myalgic Encephalomyelitis and Multiple Sclerosis Responsive to Rituximab
on 6 juin 2025
Int J Mol Sci. 2025 May 20;26(10):4885. doi: 10.3390/ijms26104885.ABSTRACTThis article summarizes the case of 30-year-old male diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and its longitudinal follow-up, which provided […]
Evaluating the Causal Role of Genetically Inferred Immune Cells and Inflammatory Cytokines on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
on 6 juin 2025
Biomedicines. 2025 May 15;13(5):1200. doi: 10.3390/biomedicines13051200.ABSTRACTBackground/Objectives: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifaceted and diverse disorder with an ambiguous etiology. Recent evidence […]
Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank
on 6 juin 2025
NIHR Open Res. 2025 Apr 28;5:39. doi: 10.3310/nihropenres.13956.1. eCollection 2025.ABSTRACTBACKGROUND: Progress in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) research is being slowed by the relatively small-scale studies being […]
MicroRNA Profiling of Blood Extracellular Vesicles in ME/CFS
on 6 juin 2025
Methods Mol Biol. 2025;2920:39-55. doi: 10.1007/978-1-0716-4498-0_4.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating neuroimmune disease affecting many organs and systems which, in the absence of […]
Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome
on 6 juin 2025
J Immunol. 2025 May 15:vkaf087. doi: 10.1093/jimmun/vkaf087. Online ahead of print.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex heterogeneous multiorgan disease that can have severe impact on individuals' quality […]
Deep Immunophenotyping in ME/CFS Using Spectral Flow Cytometry
on 6 juin 2025
Methods Mol Biol. 2025;2920:59-82. doi: 10.1007/978-1-0716-4498-0_5.ABSTRACTImmune dysfunction is reported to play a significant role in the etiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To gain an understanding of the […]
Mitochondrial Measures in Primary Cells Isolated from Patients with ME/CFS
on 6 juin 2025
Methods Mol Biol. 2025;2920:203-223. doi: 10.1007/978-1-0716-4498-0_12.ABSTRACTFibroblasts and peripheral blood mononuclear cells (PBMCs) are commonly utilized cell types for the analysis of mitochondrial function. Fibroblasts, derived from […]
Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome
on 6 juin 2025
Clin Transl Med. 2025 May;15(5):e70346. doi: 10.1002/ctm2.70346.ABSTRACTBACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness characterized by post-exertional malaise (PEM), a worsening of symptoms […]
Measuring Biomarkers of Oxidative Stress in ME/CFS Patients
on 6 juin 2025
Methods Mol Biol. 2025;2920:225-244. doi: 10.1007/978-1-0716-4498-0_13.ABSTRACTPatients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have a deficiency in energy production as a result of dysfunctions in their mitochondrial […]

Syndrome d'Ehlers-Danlos

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Revisiting Ehlers-Danlos Syndrome as a Relative Contraindication to Elective Plastic Surgery: A Retrospective Matched Cohort Study
on 6 juin 2025
Plast Reconstr Surg. 2025 May 13. doi: 10.1097/PRS.0000000000012205. Online ahead of print.ABSTRACTBACKGROUND: Ehlers-Danlos Syndromes comprise a heterogeneous group of connective tissue disorders, often associated with concerns about poor wound […]
Outcomes after Surgical Management of Large Joint Manifestations in Ehlers Danlos Syndrome and Hypermobility Conditions in Sports Medicine: a Systematic Review
on 6 juin 2025
Curr Rev Musculoskelet Med. 2025 May 21. doi: 10.1007/s12178-025-09979-2. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Joint hypermobility can increase complications in surgical management of musculoskeletal conditions. The purpose of this […]
Vascular Ehlers-Danlos syndrome: a heritable condition with potentially fatal consequences
on 6 juin 2025
Lancet Rheumatol. 2025 May 13:S2665-9913(25)00128-6. doi: 10.1016/S2665-9913(25)00128-6. Online ahead of print.NO ABSTRACTPMID:40378859 | DOI:10.1016/S2665-9913(25)00128-6
Multi-OMICs analysis on tridimensional fibroblast spheroids to model vascular Ehlers-Danlos syndrome pathogenesis
on 6 juin 2025
Biochim Biophys Acta Mol Basis Dis. 2025 May 7:167896. doi: 10.1016/j.bbadis.2025.167896. Online ahead of print.ABSTRACTThree-dimensional (3D) spheroids are an innovative cellular model mimicking tissue-like properties for a more effective […]
The Complexities of Navigating the Healthcare System as an Autistic Individual with Ehlers-Danlos Syndrome: A Patient Perspective
on 8 mai 2025
J Patient Exp. 2025 Apr 15;12:23743735251333601. doi: 10.1177/23743735251333601. eCollection 2025.ABSTRACTAutistic individuals with hypermobile Ehlers-Danlos syndrome (hEDS) often face unique challenges navigating healthcare systems due to lack of […]
Whole Blood Multi-OMIC Analysis Is Effective in Clinical Interpretation of Splicing Aberrations in PLOD1-Related Kyphoscoliotic Ehlers-Danlos Syndrome
on 8 mai 2025
Am J Med Genet A. 2025 Apr 10:e64085. doi: 10.1002/ajmg.a.64085. Online ahead of print.ABSTRACTKyphoscoliotic Ehlers-Danlos syndrome (kEDS) Type 1 is a rare hereditary connective tissue disorder due to biallelic deleterious variants in PLOD1 and is […]
HOPE for Hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD)-A Pilot Randomised Controlled Trial of Feasibility, Acceptability and Appropriateness
on 8 mai 2025
Eur J Pain. 2025 Jul;29(6):e70030. doi: 10.1002/ejp.70030.ABSTRACTBACKGROUND: Feasibility and effectiveness of online pain management programs for chronic widespread pain conditions have been shown; yet, there are no empirically evaluated programs […]
Seventeen-year outcome of surgical management of severe early onset kyphoscoliosis in a patient with arthrochalasia-type Ehlers-Danlos
on 8 mai 2025
Spine Deform. 2025 Apr 14. doi: 10.1007/s43390-025-01071-6. Online ahead of print.ABSTRACTWe report on the surgical management of severe early onset kyphoscoliosis in a 5-year-old patient with the rare arthrochalasia subtype of Ehlers-Danlos […]
Autism in the context of joint hypermobility, hypermobility spectrum disorders, and Ehlers-Danlos syndromes: A systematic review and prevalence meta-analyses
on 31 mars 2025
Autism. 2025 Mar 27:13623613251328059. doi: 10.1177/13623613251328059. Online ahead of print.ABSTRACTIncreasing research suggests a link between autism spectrum disorders and joint hypermobility, hypermobility spectrum disorders, and Ehlers-Danlos […]
Prevalence of psychiatric and sleep disorders and their impact on quality of life in children with hypermobile Ehlers-Danlos syndrome: an observational study
on 31 mars 2025
Rheumatol Int. 2025 Mar 25;45(4):81. doi: 10.1007/s00296-025-05836-0.ABSTRACTHypermobile Ehlers-Danlos Syndrome (hEDS) is the most common connective tissue disorder. However, few studies exist on psychiatric and sleep disorders in pediatric patients […]
Pregnancy and Delivery Outcomes in Vascular Ehlers-Danlos Syndrome: A Retrospective Multicentre Cohort Study
on 31 mars 2025
BJOG. 2025 Mar 19. doi: 10.1111/1471-0528.18142. Online ahead of print.ABSTRACTOBJECTIVE: We aim to increase knowledge on pregnancy and delivery risks in vascular Ehlers-Danlos Syndrome (vEDS). Our outcomes can contribute to establishing future […]
Shaping the future of care for patients with Ehlers-Danlos syndromes: from multidisciplinary management to precision medicine
on 31 mars 2025
Orphanet J Rare Dis. 2025 Mar 3;20(1):98. doi: 10.1186/s13023-025-03615-5.NO ABSTRACTPMID:40033344 | DOI:10.1186/s13023-025-03615-5
Radiographic identification of visceroptosis in hypermobile Ehlers-Danlos syndrome patients with functional gastrointestinal symptoms compared to healthy subjects
on 31 mars 2025
Clin Transl Gastroenterol. 2025 Mar 3. doi: 10.14309/ctg.0000000000000834. Online ahead of print.ABSTRACTINTRODUCTION: Visceroptosis is a potential cause of gastrointestinal symptoms in hypermobile Ehlers-Danlos syndrome (hEDS).METHODS: We […]
Recurrent perforation of an implantable cardioverter-defibrillator lead in a patient with vascular Ehlers-Danlos syndrome
on 3 mars 2025
HeartRhythm Case Rep. 2024 Oct 18;11(2):101-103. doi: 10.1016/j.hrcr.2024.10.015. eCollection 2025 Feb.NO ABSTRACTPMID:40018318 | PMC:PMC11862159 | DOI:10.1016/j.hrcr.2024.10.015
Navigating HOPE (Hypermobile Online Pain managemEnt): Perspectives and Experiences From People With Hypermobile Ehlers-Danlos Syndrome or Hypermobility Spectrum Disorder on a Condition-Specific Online Pain Management Programme
on 3 mars 2025
Health Expect. 2025 Feb;28(1):e70186. doi: 10.1111/hex.70186.ABSTRACTINTRODUCTION: The Hypermobile Online Pain managemEnt (HOPE) programme is a stakeholder informed intervention adopting the biopsychosocial pain approach, specifically for people […]
Rates of mental health concerns among individuals assessed at the GoodHope Ehlers-Danlos Syndrome Clinic
on 3 mars 2025
Orphanet J Rare Dis. 2025 Feb 14;20(1):75. doi: 10.1186/s13023-025-03550-5.ABSTRACTPast research has indicated that individuals with Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobililty Spectrum Disorder (G-HSD) report psychological and […]
Regulation of Joint Tissues and Joint Function: Is There Potential for Lessons to Be Learned Regarding Regulatory Control from Joint Hypermobility Syndromes?
on 13 février 2025
Int J Mol Sci. 2025 Jan 31;26(3):1256. doi: 10.3390/ijms26031256.ABSTRACTNormal development of joints starts in utero with the establishment of a cellular and extracellular matrix template. Following birth, individual joint tissues grow and mature […]
The Impact of Pain on Everyday Activities of People With Hypermobility Spectrum Disorders or Hypermobility Ehlers Danlos Syndrome
on 13 février 2025
Eur J Pain. 2025 Mar;29(3):e70000. doi: 10.1002/ejp.70000.ABSTRACTBACKGROUND: This study describes aspects of pain and how pain affects everyday life and examines the relation between chronic pain and activity limitations in people with […]
Efficacy of Irbesartan in Celiprolol-Treated Patients With Vascular Ehlers-Danlos Syndrome
on 13 février 2025
Circulation. 2025 Feb 5. doi: 10.1161/CIRCULATIONAHA.124.072849. Online ahead of print.ABSTRACTBACKGROUND: Vascular Ehlers-Danlos syndrome is a rare genetic disorder characterized by defective type III collagen and a high risk of arterial morbidity […]
Pediatrics. Diagnosis of generalized joint hypermobility in children
on 13 février 2025
Rev Med Suisse. 2025 Jan 29;21(903):200-204. doi: 10.53738/REVMED.2025.21.903.200.ABSTRACTJoint hypermobility is a common feature in children and adolescents, often physiological and benign, but it is also a manifestation of hereditary connective […]

Études cliniques

maladies_complexes_etudes_cliniques via biblio.chum on Inoreader

Investigating Measurable PRO Acuity Trial (IMPACT) is a Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin to Improve Neurocognitive and Physical Function of Subjects With Long COVID-19/Post-Acute Sequelae of COVID-19 (PASC).
on 6 juin 2025
Conditions: Long COVID Interventions: Drug: Maraviroc (MVC); Drug: Atorvastatin, 10mg, 20mg, 40mg; Drug: Placebo, Maraviroc; Drug: Placebo, Atorvastatin Sponsors: HealthBio, Inc. Not yet recruiting
Effectiveness of a Therapeutic Yoga Program on Fatigue and Related Variables in Patients With Chronic Fatigue Syndrome or Long Covid
on 6 juin 2025
Conditions: Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME); Post COVID Syndrome Interventions: Behavioral: Therapeutic conscious movement; Behavioral: Conventional exercise Sponsors: University of Seville Recruiting
Study to Investigate the Health Benefits of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms
on 6 juin 2025
Conditions: Long COVID Interventions: Dietary Supplement: Nasafytol® (Quercetin/Curcumin Supplement) Sponsors: Liaquat University of Medical & Health Sciences Not yet recruiting
The Canadian Respiratory Research Network Long COVID-19 Study
on 6 juin 2025
Conditions: SARS-CoV-2 Infection; Post-acute Sequelae of SARS-CoV-2 Sponsors: Sunnybrook Health Sciences Centre; Canadian Institutes of Health Research (CIHR) Completed
A Trial of Shengmai Liquid for Long COVID Fatigue.
on 6 juin 2025
Conditions: Long COVID Fatigue Interventions: Drug: Shengmai Liquid; Other: Placebo Sponsors: Beijing University of Chinese Medicine; Institute of Chemistry - Vietnam Academy of Science and Technology; Beijing Ditan Hospital Not yet recruiting
The Long COVID-19 Wearable Device Study
on 6 juin 2025
Conditions: Long COVID; Postural Orthostatic Tachycardia Syndrome; Dysautonomia; Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; Long Covid19 Interventions: Device: Wearable device Sponsors: Scripps Translational Science Institute Recruiting
Attention, Memory, Self-reflection and Insight, and Quality of Life in Adults in the Post-COVID-19 Period
on 6 juin 2025
Conditions: Post-Acute COVID-19 Syndrome; Long COVID; Brain Fog Interventions: Behavioral: qEEG-neurofeedback; Behavioral: SHAM qEEG-neurofeedback Sponsors: Jade Carvalho Da Silva; Santos Dumont Institute Not yet recruiting
Yale COVID-19 Recovery Study
on 6 juin 2025
Conditions: Covid19 Sequelae Interventions: Other: No intervention Sponsors: Yale University; Food and Drug Administration (FDA) Completed
Long Term Effects of Awake Prone Positioning in COVID-19 ICU Patients
on 6 juin 2025
Conditions: SARS-CoV 2 Pneumonia Interventions: Other: quality of life questionnaire Sponsors: University Hospital, Tours Recruiting
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
on 6 juin 2025
Conditions: Anosmia; Asymptomatic COVID-19; COVID-19 Respiratory Infection; Influenza; Healthy; PASC Post Acute Sequelae of COVID 19 Interventions: Device: AROMHA Longitudinal Smell Test Sponsors: Massachusetts General Hospital; National Institute […]
Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With Postural Orthostatic Tachycardia Syndrome.
on 6 juin 2025
Conditions: Postural Orthostatic Tachycardia Syndrome (POTS); Post-acute COVID-19 Syndromes Interventions: Device: TVNS + Slow-Paced Breathing (TVNS+SDB); Device: TVNS without Breathing Training (TVNS+NB); Device: Sham TVNS + SDB; Device: Sham TVNS […]
Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes in the Lungs After COVID-19
on 6 juin 2025
Conditions: Post-Acute COVID-19 Syndrome; Lung Disease With Polymyositis; Fibrosis; Lung Diseases, Interstitial; Lung; Disease, Interstitial, With Fibrosis Interventions: Drug: Longidaza®; Drug: Placebo Sponsors: NPO Petrovax Completed
Effects of an Active Coping Program in Patients With Persistent Post-Covid Pain.
on 6 juin 2025
Conditions: Long COVID; Pain Interventions: Behavioral: Pain Neuroscience Education (PNE)+ Therapeutic Exercise (TE); Behavioral: Active Comparator: Usual treatment Sponsors: University of Valladolid Completed
Quality of Life After Hyperbaric Oxygen Therapy in Post-COVID Patients
on 6 juin 2025
Conditions: Long COVID; Long COVID-19 Syndrome; Long Covid19; Long Covid 19 Interventions: Other: Hyperbaric oxygen therapy Sponsors: Rutger Lalieu Active, not recruiting
Biomarkers of LONG COVID (LONG COVID_LCM)
on 6 juin 2025
Conditions: Long COVID Interventions: Diagnostic Test: Measurement of ncRNAs and cytokines Sponsors: IRCCS Policlinico S. Donato Completed
Observational Study of Intranasal IVIG and RXRA Gene Expression in Long COVID Patients Undergoing Medical Tourism
on 6 juin 2025
Conditions: Post-Acute Sequelae of SARS-CoV-2 Infection; Long COVID; Long COVID Fatigue; Long COVID Syndrome; COVID 19 Associated Coagulopathy; COVID-19 Vaccination Sponsors: Healing Hope International Not yet recruiting
Vagus Nerve Stimulation to the Ear to Improve Symptoms in Post-COVID-19 and ME/CFS
on 6 juin 2025
Conditions: Post-COVID / Long-COVID; ME/CFS Interventions: Device: transcutaneous vagus nerve stimulation; Device: transcutaneous vagus nerve stimulation Sponsors: University of Luxembourg Recruiting
Exploring the Therapeutic Effects of Creatine Supplementation for Long COVID
on 6 juin 2025
Conditions: Long COVID Fatigue Interventions: Dietary Supplement: Creatine monohydrate Sponsors: University of Calgary Not yet recruiting
Long COVID Cutaneous Signatures: An ARPA Funded Research Project
on 6 juin 2025
Conditions: Long COVID; Acute COVID-19; Postural Orthostatic Tachycardia Syndrome (POTS); Diabetic Neuropathy Sponsors: CND Life Sciences Recruiting
Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19
on 8 mai 2025
Conditions: Long COVID-19 Interventions: Drug: Low-dose sirolimus; Drug: Placebo Sponsors: Icahn School of Medicine at Mount Sinai; PolyBio Research Foundation; The Anlyan Center Not yet recruiting

Revue d'actualités

maladies_complexes_actualites via biblio.chum on Inoreader

Réplique | Maladie de Lyme persistante : primum non nocere !
on 13 juin 2025
Deux chroniques récentes d’Isabelle Hachey portent préjudice aux patients de la maladie de Lyme persistante et attaquent ma réputation. La chroniqueuse sème le doute sur l’existence de la condition et sur mes compétences. Elle accuse […]
Would you recognize these Lyme disease rashes? : Johns Hopkins Lyme Disease Research Center
on 6 juin 2025
Sometimes, but not usually, a ring within a ring Bull’s-eye rash appearance Often mistaken for a spider bite but is not a spider bite Not always present. Not everyone has a rash. More difficult to discern in darker-skinned indivduals. Large […]
Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID - Nature
on 6 juin 2025
Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID Nature
Long-Haul COVID-19 Treatment | Stanford Health Care | Stanford ...
on 6 juin 2025
Our clinic provides comprehensive testing and management plans individualized to your needs and goals.
Maladie de Lyme | L’effet Khadir - La Presse
on 6 juin 2025
Maladie de Lyme | L’effet Khadir La Presse
S4 EP1 - Le labyrinthe de Lyme : repartir de zéro - Radio-Canada
on 6 juin 2025
S4 EP1 - Le labyrinthe de Lyme : repartir de zéro Radio-Canada
Olivier Bernard décortique la souffrance associée à la maladie de Lyme - Radio-Canada
on 6 juin 2025
Olivier Bernard décortique la souffrance associée à la maladie de Lyme Radio-Canada
Encore de nombreux cas de la maladie de Lyme attendus au Québec en 2025 - Le Devoir
on 6 juin 2025
Encore de nombreux cas de la maladie de Lyme attendus au Québec en 2025 Le Devoir
Tiques : comment prévenir la maladie de Lyme? - Radio-Canada
on 6 juin 2025
Tiques : comment prévenir la maladie de Lyme? Radio-Canada
Balado d’Olivier Bernard | Dans l’abîme de Lyme - La Presse
on 6 juin 2025
Balado d’Olivier Bernard | Dans l’abîme de Lyme La Presse
Covid long : réintégration et soutien pratique sur le lieu de travail
on 8 mai 2025
L’EU-OSHA publie quelques nouveaux documents contenant des informations et des conseils sur la manière d’aider les travailleurs touchés par un Covid long, soulignant également l’importance de la réintégration et de l’accompagnement dans […]
Discovery explains Long COVID breathing problems - EurekAlert!
on 8 mai 2025
Discovery explains Long COVID breathing problems EurekAlert!
Long COVID May Cause Long-Term Changes in the Heart and Lungs and May Lead to Cardiac and Pulmonary Diseases - Mount Sinai
on 8 mai 2025
Long COVID May Cause Long-Term Changes in the Heart and Lungs and May Lead to Cardiac and Pulmonary Diseases Mount Sinai
Long Covid is neither psychological nor physical - ScienceNorway
on 8 mai 2025
Long Covid is neither psychological nor physical ScienceNorway
Beyond long COVID — how reinfections could be causing silent long-term organ damage - CBC.ca
on 31 mars 2025
Beyond long COVID — how reinfections could be causing silent long-term organ damage CBC.ca
COVID longue : des manifestants veulent davantage de recherche - Radio-Canada
on 31 mars 2025
COVID longue : des manifestants veulent davantage de recherche Radio-Canada
Les dés pipés de la COVID longue - Le Soleil
on 31 mars 2025
Les dés pipés de la COVID longue Le Soleil
Quand la guerre contre la COVID longue se livre à trois - Radio-Canada
on 31 mars 2025
Quand la guerre contre la COVID longue se livre à trois Radio-Canada
Un sportif de 19 ans passe maintenant ses journées alité à cause de la COVID longue durée - Le Journal de Montréal
on 31 mars 2025
Un sportif de 19 ans passe maintenant ses journées alité à cause de la COVID longue durée Le Journal de Montréal
La COVID longue, un pénible héritage de la pandémie - Radio-Canada
on 31 mars 2025
La COVID longue, un pénible héritage de la pandémie Radio-Canada

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